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Some low\u2010to\u2010medium risk genes in melanoma susceptibility play a role in melanoma outcome. Our aim was to assess the role of the functional\n                    <jats:italic>IRF4<\/jats:italic>\n                    SNP rs12203592 in melanoma prognosis in two independent sets (Barcelona,\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009493 and Essen,\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009438). Genotype association analyses showed that the\n                    <jats:italic>IRF4<\/jats:italic>\n                    rs12203592 T allele increased the risk of dying from melanoma in both sets (Barcelona: odds ratio [OR]\u00a0=\u00a06.53, 95% CI 1.38\u201330.87, Adj\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.032; Essen: OR\u2009=\u20091.68, 95% CI 1.04\u20132.72, Adj\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.035). Survival analyses only showed significance for the Barcelona set (hazard ratio\u2009=\u20094.58, 95% CI 1.11\u201318.92, Adj\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.036). This SNP was also associated with tumour localization, increasing the risk of developing melanoma in head or neck (OR\u2009=\u20091.79, 95% CI 1.07\u20132.98, Adj\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.032) and protecting from developing melanoma in the trunk (OR\u2009=\u20090.59, 95% CI 0.41\u20130.85, Adj\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). These findings suggest for the first time that\n                    <jats:italic>IRF4<\/jats:italic>\n                    rs12203592 plays a role in the modulation of melanoma outcome and confirms its contribution to the localization of the primary tumour.\n                  <\/jats:p>","DOI":"10.1002\/ijc.30605","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T00:43:11Z","timestamp":1484872991000},"page":"1845-1849","source":"Crossref","is-referenced-by-count":19,"title":["<i>IRF4<\/i>\n                    rs12203592 functional variant and melanoma survival"],"prefix":"10.1002","volume":"140","author":[{"given":"Miriam","family":"Potrony","sequence":"first","affiliation":[{"name":"Dermatology Department Melanoma Unit, Hospital Cl\u00ednic de Barcelona, IDIBAPS, Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Rebollo\u2010Morell","sequence":"additional","affiliation":[{"name":"Dermatology Department Melanoma Unit, Hospital Cl\u00ednic de Barcelona, IDIBAPS, Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pol","family":"Gim\u00e9nez\u2010Xavier","sequence":"additional","affiliation":[{"name":"Dermatology Department Melanoma Unit, Hospital Cl\u00ednic de Barcelona, IDIBAPS, Universitat de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Raras (CIBERER) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Essen, Essen, Germany &amp; 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German Cancer Consortium Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Puig","sequence":"additional","affiliation":[{"name":"Dermatology Department Melanoma Unit, Hospital Cl\u00ednic de Barcelona, IDIBAPS, Universitat de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Raras (CIBERER) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4799"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.10.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0901"},{"key":"e_1_2_7_5_1","first-page":"210","article-title":"Update in genetic susceptibility in melanoma","volume":"3","author":"Potrony M","year":"2015","journal-title":"Ann Transl Med"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.00982.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29317"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11624"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1444"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28796"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.498"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26023"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv157"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.05.017"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1375\/twin.14.5.422"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-160"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000081726.49886.CF"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.022"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl268"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29525"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10630"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.4356"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07674"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.10.015"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30184"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw004"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29335"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12829"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.30605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.30605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.30605","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.30605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T11:08:17Z","timestamp":1694171297000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.30605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,6]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,4,15]]}},"alternative-id":["10.1002\/ijc.30605"],"URL":"https:\/\/doi.org\/10.1002\/ijc.30605","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,6]]}}}