{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:52:55Z","timestamp":1779115975713,"version":"3.51.4"},"reference-count":128,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372916"],"award-info":[{"award-number":["81372916"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,8,15]]},"abstract":"<jats:p>Melanoma is a most aggressive skin cancer with limited therapeutic options and its incidence is increasing rapidly in recent years. The discovery and application of new targeted therapy agents have shown significant benefits. However, adverse side\u2010effects and resistance to chemotherapy remain formidable challenges in the clinical treatment of malignant melanoma. Nanotherapeutics offers an important prospect of overcoming these drawbacks. The anti\u2010tumoral applications of nanomedicine are varied, including those in chemotherapy, RNA interference, photothermal therapy, and photodynamic therapy. Furthermore, nanomedicine allows delivery of the effector structures into the tumor site via passive or active targeting, thereby allowing increased therapeutic specificity and reduced side effects. In this review, we summarize the latest developments in the application of nanocarrier\u2010mediated targeted drug delivery to melanoma and nanomedicine\u2010related clinical trials in melanoma treatment. We also discuss existing problems and opportunities for future developments, providing direction and new thoughts for further studies.<\/jats:p>","DOI":"10.1002\/ijc.30708","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T09:04:58Z","timestamp":1490432698000},"page":"646-653","source":"Crossref","is-referenced-by-count":48,"title":["Recent developments in nanomedicine for melanoma treatment"],"prefix":"10.1002","volume":"141","author":[{"given":"Jian\u2010Qin","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Xuzhou Medical University Xuzhou 221002 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Yang","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Xuzhou Medical University Xuzhou 221002 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Sheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Huai'an Hospital of Xuzhou Medical University Huai'an 223002 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Xi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Xuzhou Medical University Xuzhou 221002 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Affiliated Hospital of Xuzhou Medical University Xuzhou 221002 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Wen","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Affiliated Hospital of Xuzhou Medical University Xuzhou 221002 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Ping","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Xuzhou Medical University Xuzhou 221002 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Qun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Xuzhou Medical University Xuzhou 221002 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0705-2386","authenticated-orcid":false,"given":"Guan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Xuzhou Medical University Xuzhou 221002 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0025-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2009.08.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.1.158"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PPO.0000581876.62921.87"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0391"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.09.019"},{"key":"e_1_2_8_10_1","first-page":"159","article-title":"Nanodrug delivery in reversing multidrug resistance in cancer cells","volume":"5","author":"Kapse\u2010Mistry S","year":"2014","journal-title":"Front Pharmacol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/60879"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21199"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2011.599049"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2015.1051049"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn102324e"},{"key":"e_1_2_8_16_1","first-page":"30003","article-title":"Nanotechnology\u2010based strategies for combating toxicity and resistance in melanoma therapy","volume":"28","author":"Brys AK","year":"2016","journal-title":"Biotechnol Adv"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.13.80"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S62057"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-014-0386-6"},{"key":"e_1_2_8_20_1","first-page":"14","article-title":"Cerium oxide nanoparticles induce oxidative stress and genotoxicity in human skin melanoma cells","volume":"14","author":"Ali D","year":"2014","journal-title":"Cell Biochem Biophys"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10915810600959543"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2012.10.010"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2013.02.005"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.05.005"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2014.02.038"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2013.12.015"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-016-0162-3"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8532"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568011024606370"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20160"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2014.1786"},{"key":"e_1_2_8_32_1","first-page":"320","article-title":"Improving chemoradiotherapy with nanoparticle therapeutics","volume":"2","author":"Eblan MJ","year":"2013","journal-title":"Transl Cancer Res"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjnano.6.59"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2008.07.010"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic301050v"},{"key":"e_1_2_8_36_1","first-page":"4121","article-title":"Selective cytotoxicity of PAMAM G5 core\u2013PAMAM G2.5 shell tecto\u2010dendrimers on melanoma cells","volume":"7","author":"Schilrreff P","year":"2012","journal-title":"Int J Nanomed"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4831"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2014_085"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2008.275"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2015.9092"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.15.178"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbw011"},{"key":"e_1_2_8_43_1","first-page":"0","article-title":"Nanomaterials in food and agriculture: an overview on their safety concerns and regulatory issues","volume":"6","author":"Jain A","year":"2016","journal-title":"Crit Rev Food Sci Nutr"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.314"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers5010296"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666160209152446"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.12.87"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2014.05.005"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2015.03.001"},{"key":"e_1_2_8_50_1","first-page":"1","article-title":"Nanotechnology\u2010based drug delivery systems and herbal medicines: a review","volume":"9","author":"Silva P","year":"2014","journal-title":"Int J Nanomed"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-015-0462-2"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2015.07.010"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.01.005"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.10.057"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S96614"},{"key":"e_1_2_8_56_1","first-page":"11","article-title":"Tumor refractoriness to anti\u2010VEGF therapy","author":"Ribatti D.","year":"2016","journal-title":"Oncotarget"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-015-9769-3"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2015.2016"},{"key":"e_1_2_8_59_1","first-page":"575","article-title":"Sustained\u2010and controlled\u2010release drug delivery systems","volume":"72","author":"Jantzen GM","year":"1996","journal-title":"Drugs the Pharm Sci"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn5010815"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.033"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.166173"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.03.014"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30033-X"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666160304151011"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133165"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4267"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-016-2122-7"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.07.012"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-015-0113-5"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.05.043"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2015.1919"},{"key":"e_1_2_8_73_1","first-page":"1991","article-title":"Anti\u2010DR5 monoclonal antibody\u2010mediated DTIC\u2010loaded nanoparticles combining chemotherapy and immunotherapy for malignant melanoma: target formulation development and in vitro anticancer activity","volume":"6","author":"Ding B","year":"2011","journal-title":"Int J Nanomed"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.14527"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.10804"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn405383a"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-013-1176-3"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR07928D"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.04.042"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2012.01.003"},{"key":"e_1_2_8_81_1","first-page":"2437","article-title":"Quantum dots affect expression of CD133 surface antigen in melanoma cells","volume":"6","author":"Steponkiene S","year":"2011","journal-title":"Int J Nanomedicine"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg908"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03668-8"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.91"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.4018"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.11.003"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.12.026"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201301992"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.135"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.270"},{"key":"e_1_2_8_91_1","first-page":"991","article-title":"Insights into the therapeutic potential of hypoxia\u2010inducible factor\u20101alpha small interfering RNA in malignant melanoma delivered via folate\u2010decorated cationic liposomes","volume":"11","author":"Chen Z","year":"2016","journal-title":"Int J Nanomed"},{"key":"e_1_2_8_92_1","doi-asserted-by":"crossref","first-page":"14940","DOI":"10.18632\/oncotarget.7496","article-title":"Salmonella VNP20009\u2010mediated RNA interference of ABCB5 moderated chemoresistance of melanoma stem cell and suppressed tumor growth more potently","volume":"7","author":"Zhang X","year":"2016","journal-title":"Oncotarget"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.03.010"},{"key":"e_1_2_8_94_1","first-page":"1553","article-title":"Small interfering RNA (siRNA)\u2010mediated knockdown of Notch1 suppresses tumor growth and enhances the effect of IL\u20102 immunotherapy in malignant melanoma","volume":"20","author":"Yang Z","year":"2015","journal-title":"J Buon"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12330"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144241"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23356"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201002820"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201402092"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b02270"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2015-0011"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1480"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1847-x"},{"key":"e_1_2_8_104_1","first-page":"607","article-title":"A novel redox\u2010sensitive system based on single\u2010walled carbon nanotubes for chemo\u2010photothermal therapy and magnetic resonance imaging","volume":"11","author":"Hou L","year":"2016","journal-title":"Int J Nanomed"},{"key":"e_1_2_8_105_1","first-page":"980","article-title":"Photothermal effects of metallic carbon nanotubes on human breast cancer cells","volume":"50","author":"Hou J","year":"2015","journal-title":"Yao Xue Xue Bao"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.08.001"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2014.09.033"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2016.09.012"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3NR06835H"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.10.029"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.10.11.13434"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S69550"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR02196K"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201500550"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201501197"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201403315"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.11.068"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b05097"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21030342"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.04.014"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20984"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2012.01.007"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.08.010"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.09.032"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160920943"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b05763"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201403193"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.03.065"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-014-1193-7"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.30708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.30708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T20:57:26Z","timestamp":1696539446000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.30708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,6]]},"references-count":128,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8,15]]}},"alternative-id":["10.1002\/ijc.30708"],"URL":"https:\/\/doi.org\/10.1002\/ijc.30708","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,6]]}}}