{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:54:49Z","timestamp":1790146489841,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T00:00:00Z","timestamp":1492560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"HPV-AHEAD","award":["FP7-HEALTH-2011-282562"],"award-info":[{"award-number":["FP7-HEALTH-2011-282562"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Mucosal high\u2010risk (HR) human papillomaviruses (HPV) cause a subset of head and neck cancers (HNC). The HPV\u2010attributable fraction of HNC varies substantially between countries. Although HNC has a very high incidence in the Indian subcontinent, information on the contribution of HPV infection is limited. Here, we evaluated the HPV\u2010attributable fraction in HNC (<jats:italic>N<\/jats:italic>\u2009=\u2009364) collected in a central region of India. HNC from three different anatomical subsites were included, namely, oral cavity (<jats:italic>n<\/jats:italic>\u2009=\u2009252), oropharynx (<jats:italic>n<\/jats:italic>\u2009=\u200953) and hypopharynx\/larynx (<jats:italic>n<\/jats:italic>\u2009=\u200959). In this retrospective study, HPV\u2010driven HNC were defined by presence of both viral DNA and RNA. Overexpression of p16<jats:sup>INK4a<\/jats:sup> was also evaluated. HR\u2010HPV DNA was detected in 13.7% of the cases; however, only 2.7% were positive for both HPV DNA and RNA. The highest percentage of HPV DNA\/RNA double positivity was found in oropharynx (9.4%), followed by larynx (1.7%) and oral cavity (1.6%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.02). More than half of HPV DNA\/RNA\u2010positive cases were p16<jats:sup>INK4a<\/jats:sup>\u2010negative, while a considerable number of HPV RNA\u2010negative cases were p16<jats:sup>INK4a<\/jats:sup>\u2010positive (17.9%). HPV16 was the major type associated with HNC (60.0%), although cases positive for HPV18, 35 and 56 were also detected. Our data indicate that the proportion and types of mucosal HR\u2010HPV associated with HNC in this central Indian region differ from those in other (developed) parts of the world. This may be explained by differences in smoking and\/or sexual behaviour compared with North America and northern Europe. Moreover, we show that p16<jats:sup>INK4a<\/jats:sup> staining appeared not to be a good surrogate marker of HPV transformation in the Indian HNC cases.<\/jats:p>","DOI":"10.1002\/ijc.30712","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T18:28:32Z","timestamp":1490812112000},"page":"143-151","source":"Crossref","is-referenced-by-count":42,"title":["Role of mucosal high\u2010risk human papillomavirus types in head and neck cancers in central India"],"prefix":"10.1002","volume":"141","author":[{"given":"Tarik","family":"Gheit","sequence":"first","affiliation":[{"name":"International Agency for Research on Cancer Lyon 69008 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devasena","family":"Anantharaman","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer Lyon 69008 France"},{"name":"Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram 695014 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