{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T19:19:42Z","timestamp":1793992782070,"version":"4.8.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:00:00Z","timestamp":1496880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/igo\/legalcode"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","award":["00039621"],"award-info":[{"award-number":["00039621"]}],"id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1053353"],"award-info":[{"award-number":["OPP1053353"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,8,15]]},"abstract":"<jats:p>HPV is the cause of almost all cervical cancer and is responsible for a substantial fraction of other anogenital cancers and oropharyngeal cancers. Understanding the HPV\u2010attributable cancer burden can boost programs of HPV vaccination and HPV\u2010based cervical screening. Attributable fractions (AFs) and the relative contributions of different HPV types were derived from published studies reporting on the prevalence of transforming HPV infection in cancer tissue. Maps of age\u2010standardized incidence rates of HPV\u2010attributable cancers by country from GLOBOCAN 2012 data are shown separately for the cervix, other anogenital tract and head and neck cancers. The relative contribution of HPV16\/18 and HPV6\/11\/16\/18\/31\/33\/45\/52\/58 was also estimated. 4.5% of all cancers worldwide (630,000 new cancer cases per year) are attributable to HPV: 8.6% in women and 0.8% in men. AF in women ranges from &lt;3% in Australia\/New Zealand and the USA to &gt;20% in India and sub\u2010Saharan Africa. Cervix accounts for 83% of HPV\u2010attributable cancer, two\u2010thirds of which occur in less developed countries. Other HPV\u2010attributable anogenital cancer includes 8,500 vulva; 12,000 vagina; 35,000 anus (half occurring in men) and 13,000 penis. In the head and neck, HPV\u2010attributable cancers represent 38,000 cases of which 21,000 are oropharyngeal cancers occurring in more developed countries. The relative contributions of HPV16\/18 and HPV6\/11\/16\/18\/31\/33\/45\/52\/58 are 73% and 90%, respectively. Universal access to vaccination is the key to avoiding most cases of HPV\u2010attributable cancer. The preponderant burden of HPV16\/18 and the possibility of cross\u2010protection emphasize the importance of the introduction of more affordable vaccines in less developed countries.<\/jats:p>","DOI":"10.1002\/ijc.30716","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T09:50:12Z","timestamp":1491299412000},"page":"664-670","source":"Crossref","is-referenced-by-count":2171,"title":["Worldwide burden of cancer attributable to HPV by site, country and HPV type"],"prefix":"10.1002","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3642-277X","authenticated-orcid":false,"given":"Catherine","family":"de Martel","sequence":"first","affiliation":[{"name":"International Agency for Research on Cancer Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn","family":"Plummer","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Vignat","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Franceschi","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70237-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(16)30099-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.07.038"},{"key":"e_1_2_7_5_1","first-page":"1","article-title":"Human papillomaviruses","volume":"64","author":"IARC","year":"1995","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"Human Papillomaviruses","volume":"90","author":"IARC","year":"2007","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_7_7_1","first-page":"1","article-title":"Biological Agents","volume":"100","author":"IARC","year":"2012","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv302"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(16)30143-7"},{"key":"e_1_2_7_10_1","unstructured":"FerlayJ SoerjomataramI ErvikM et al. 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