{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:59:55Z","timestamp":1774367995574,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National High Technology Research and Development Program of China (863 Program), China","award":["2015AA020103"],"award-info":[{"award-number":["2015AA020103"]}]},{"name":"Natural Science Foundation of Guangdong Province, China","award":["2014A030313205"],"award-info":[{"award-number":["2014A030313205"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Several non\u2010hepatocellular cancers were linked with hepatitis B virus (HBV) infection. This study was aimed to quantify the potential associations between HBV infection and multiple non\u2010hepatocellular cancers. Continuous cases, including 5,715 non\u2010cancer and 40,963 cancer cases diagnosed from 2008 to 2014 in Sun Yat\u2010sen University Cancer Center were analyzed. HBV DNA and hepatitis B core antigen (HBcAg) were examed in gastric cancer tissues by polymerase chain reaction and immunohistochemical staining. After adjusting for age, sex, year of diagnosis, smoking, drinking and family history of cancer, significant associations were found between serum HBsAg and frequently reported HBV\u2010related non\u2010hepatocellular cancers, including non\u2010Hodgkin's lymphoma, cholangiocarcinoma and pancreatic cancer [adjusted odds ratio (AOR) and 95% confidence interval (CI): 1.89 (1.65\u20132.16)], as well as total other non\u2010hepatocellular cancers [AOR and 95% CI: 1.12 (1.03\u20131.22)]. The median ages at diagnosis, all\u2010cause death and cancer\u2010specific death of serum HBsAg positive cancer patients were all significantly younger than those with serum HBsAg negative. HBV DNA was detected in 12.4% (34\/275) gastric cancer tissues and HBcAg was most commonly detected in lymphocytes. This was the first report that HBV infection had a modest but significant nonspecific association with total non\u2010hepatocellular cancers. Median age at diagnosis and death was significantly younger in serum HBsAg positive cancer patients. The underlying mechanism needs further investigation.<\/jats:p>","DOI":"10.1002\/ijc.30719","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T12:50:29Z","timestamp":1491310229000},"page":"152-159","source":"Crossref","is-referenced-by-count":37,"title":["Hepatitis B virus infection is associated with younger median age at diagnosis and death in cancers"],"prefix":"10.1002","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-3237","authenticated-orcid":false,"given":"Xiao\u2010li","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010yan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010feng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Information Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao\u2010lei","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huai\u2010qiang","family":"Ju","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi\u2010nian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010jie","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan\u2010li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010hua","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010zhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010hong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9771-8534","authenticated-orcid":false,"given":"Rui\u2010hua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61412-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.061"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22549"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70167-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24150"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26376"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.3526"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.18.2010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22606"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70207-X"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.04.021"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.406"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70077-X"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0344"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27406"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-8-126"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.03.001"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-115"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28196"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.02.005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-249"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.2.713"},{"key":"e_1_2_8_24_1","first-page":"492","article-title":"Establishing the link between hepatitis B virus infection and colorectal adenoma","volume":"6","author":"Patel BB","year":"2015","journal-title":"J Gastrointest Oncol"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907013410104"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.05.043"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180406"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90916-9"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940215)73:4<1143::AID-CNCR2820730404>3.0.CO;2-U"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(86)80152-0"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890310413"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2003.02376.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.157"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.34.7_suppl.138"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27609"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.10.039"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.010"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28156"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.30719","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.30719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:29:22Z","timestamp":1696400962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.30719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,24]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/ijc.30719"],"URL":"https:\/\/doi.org\/10.1002\/ijc.30719","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,24]]}}}