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Here, we investigated associations between genetic variants of Rho GTPases\u2010related genes and cutaneous melanoma\u2010specific survival (CMSS) by re\u2010analyzing a published melanoma genome\u2010wide association study (GWAS) and validating the results in another melanoma GWAS. In the single\u2010locus analysis of 36,018 SNPs in 129 Rho\u2010related genes, 427 SNPs were significantly associated with CMSS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.050 and false\u2010positive report probability &lt;0.2) in the discovery dataset, and five SNPs were replicated in the validation dataset. Among these, four SNPs (<jats:italic>i.e<\/jats:italic>., <jats:italic>RHOU<\/jats:italic> rs10916352 G\u2009&gt;\u2009C, <jats:italic>ARHGAP22<\/jats:italic> rs3851552 T\u2009&gt;\u2009C, <jats:italic>ARHGAP44<\/jats:italic> rs72635537 C\u2009&gt;\u2009T and <jats:italic>ARHGEF10<\/jats:italic> rs7826362 A\u2009&gt;\u2009T) were independently predictive of CMSS (a meta\u2010analysis derived <jats:italic>p<\/jats:italic>\u2009=\u20099.04 \u00d7 10<jats:sup>\u22124<\/jats:sup>, 9.58 \u00d7 10<jats:sup>\u22124<\/jats:sup>, 1.21 \u00d7 10<jats:sup>\u22124<\/jats:sup> and 8.47 \u00d7 10<jats:sup>\u22124<\/jats:sup>, respectively). Additionally, patients with an increasing number of unfavorable genotypes (NUGs) of these loci had markedly reduced CMSS in both discovery dataset and validation dataset (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>=1.47 \u00d7 10<jats:sup>\u22127<\/jats:sup> and 3.12 \u00d7 10<jats:sup>\u22125<\/jats:sup>). The model including the NUGs and clinical variables demonstrated a significant improvement in predicting the five\u2010year CMSS. Moreover, rs10916352C and rs3851552C alleles were significantly associated with an increased mRNA expression levels of <jats:italic>RHOU<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009=\u20091.8 \u00d7 10<jats:sup>\u22126<\/jats:sup>) and <jats:italic>ARHGAP22<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009=\u20095.0 \u00d7 10<jats:sup>\u22126<\/jats:sup>), respectively. These results may provide promising prognostic biomarkers for CM personalized management and treatment.<\/jats:p>","DOI":"10.1002\/ijc.30785","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T16:24:49Z","timestamp":1494951889000},"page":"721-730","source":"Crossref","is-referenced-by-count":10,"title":["Genetic variants in the genes encoding rho GTPases and related regulators predict cutaneous melanoma\u2010specific survival"],"prefix":"10.1002","volume":"141","author":[{"given":"Shun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Epidemiology School of Public Health, Guangxi Medical University Nanning Guangxi 530021 China"},{"name":"Duke Cancer Institute, Duke University Medical Center Durham NC 27710"},{"name":"Department of Medicine Duke University School of Medicine Durham NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanru","family":"Wang","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, Duke University Medical Center Durham NC 27710"},{"name":"Department of Medicine Duke University School of Medicine Durham NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Xue","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, Duke University Medical Center Durham NC 27710"},{"name":"Department of Medicine Duke University School of Medicine Durham NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7639-0904","authenticated-orcid":false,"given":"Hongliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, Duke University Medical Center Durham NC 27710"},{"name":"Department of Medicine Duke University School of Medicine Durham NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghui","family":"Xu","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, Duke University Medical Center Durham NC 27710"},{"name":"Department of Medicine Duke University School of Medicine Durham NC 27710"},{"name":"Cancer Center, The First Hospital of Jilin University Changchun Jilin 130021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Shi","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, Duke University Medical Center Durham NC 27710"},{"name":"Department of Medicine Duke University School of Medicine Durham NC 27710"},{"name":"Department of Dermatology Xijing Hospital Xi'an Shanxi 710032 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Fairbanks School of Public Health, and Melvin and Bren Simon Cancer Center, Indiana University Indianapolis IN 46202"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dakai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Community and Family Medicine Geisel School of Medicine, Dartmouth College Hanover NH 03755"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher I.","family":"Amos","sequence":"additional","affiliation":[{"name":"Community and Family Medicine Geisel School of Medicine, Dartmouth College Hanover NH 03755"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenying","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Texas M. 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