{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:57:12Z","timestamp":1791356232525,"version":"4.3.1"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:00:00Z","timestamp":1496188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA114236"],"award-info":[{"award-number":["R01 CA114236"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA129639"],"award-info":[{"award-number":["R01 CA129639"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA97397"],"award-info":[{"award-number":["R01 CA97397"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 CA83178"],"award-info":[{"award-number":["U01 CA83178"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Alcohol drinking and, to a lesser extent, cigarette smoking are risk factors for a first primary breast cancer. Information on these behaviours at diagnosis may contribute to risk prediction of contralateral breast cancer (CBC) and they are potentially modifiable. The WECARE Study is a large population\u2010based case\u2010control study of women with breast cancer where cases (<jats:italic>N<\/jats:italic>\u2009=\u20091,521) had asynchronous CBC and controls (<jats:italic>N<\/jats:italic>\u2009=\u20092,212), matched on survival time and other factors, had unilateral breast cancer (UBC). Using multivariable conditional logistic regression to estimate rate ratios (RR) and 95% confidence intervals (CI), we examined the risk of CBC in relation to drinking and smoking history at and following first diagnosis. We adjusted for treatment, disease characteristics and other factors. There was some evidence for an association between CBC risk and current drinking or current smoking at the time of first breast cancer diagnosis, but the increased risk occurred primarily among women exposed to both (RR\u2009=\u20091.62, 95% CI 1.24\u20132.11). CBC risk was also elevated in women who both smoked and drank alcohol after diagnosis (RR\u2009=\u20091.54, 95% CI 1.18\u20131.99). In the subset of women with detailed information on amount consumed, smoking an average of \u226510 cigarettes per day following diagnosis was also associated with increased CBC risk (RR\u2009=\u20091.50, 95% CI 1.08\u20132.08; <jats:italic>p<\/jats:italic>\u2010trend\u2009=\u20090.03). Among women with a diagnosis of breast cancer, information on current drinking and smoking could contribute to the prediction of CBC risk. Women who both drink and smoke may represent a group who merit targeted lifestyle intervention to modify their risk of CBC.<\/jats:p>","DOI":"10.1002\/ijc.30791","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T12:14:19Z","timestamp":1495196059000},"page":"916-924","source":"Crossref","is-referenced-by-count":48,"title":["Alcohol consumption and cigarette smoking in combination: A predictor of contralateral breast cancer risk in the WECARE study"],"prefix":"10.1002","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7610-7635","authenticated-orcid":false,"given":"Julia A.","family":"Knight","sequence":"first","affiliation":[{"name":"Prosserman Centre for Health Research, Lunenfeld\u2010Tanenbaum Research Institute, Sinai Health System Toronto ON Canada"},{"name":"Epidemiology Division, Dalla Lana School of Public Health University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fan","sequence":"additional","affiliation":[{"name":"Prosserman Centre for Health Research, Lunenfeld\u2010Tanenbaum Research Institute, Sinai Health System Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen E.","family":"Malone","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Research Center Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther M.","family":"John","sequence":"additional","affiliation":[{"name":"Division of Epidemiology Cancer Prevention Institute of California Fremont CA"},{"name":"Department of Health Research and Policy (Epidemiology) and Stanford Cancer Institute Stanford University School of Medicine Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Pathology University of Iowa Iowa City IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke","family":"Langballe","sequence":"additional","affiliation":[{"name":"Virus, Lifestyle and Genes Unit, Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Beckman Research Institute, City of Hope National Medical Center Duarte CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy E.","family":"Shore","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine New York University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer D.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Epidemiology Division, Dalla Lana School of Public Health University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne S.","family":"Reiner","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Woods","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Liang","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonine L.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center New York 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