{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:39Z","timestamp":1786977939838,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:00:00Z","timestamp":1496880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA179129"],"award-info":[{"award-number":["R01 CA179129"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA133891"],"award-info":[{"award-number":["R01 CA133891"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>\n                    Obesity is associated with an increased risk of fatal prostate cancer. We aimed to elucidate the importance and relevant timing of obesity and weight change for prostate cancer progression. We identified 5,158 men diagnosed with localized prostate cancer (clinical stage T1\/T2) from 1986 to 2012 in the Health Professionals Follow\u2010up Study. Men were followed for biochemical recurrence and lethal prostate cancer (development of distant metastasis or prostate cancer\u2010specific mortality) until 2012. Cox regression estimated hazard ratios (HRs) for body mass index (BMI) at age 21, BMI at diagnosis, \u201clong\u2010term\u201d weight change from age 21 to diagnosis and \u201cshort\u2010term\u201d weight change over spans of 4 and 8 years preceding diagnosis. Because weight, weight change and mortality are strongly associated with smoking, we repeated analyses among never smokers only (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20092,559). Among all patients, neither weight change nor BMI (at age 21 or at diagnosis) was associated with lethal prostate cancer. Among never smokers, long\u2010term weight gain was associated with an increased risk of lethal disease (HR for gaining &gt;30 pounds vs. stable weight [\u00b110 pounds] 1.59, 95% CI, 1.01\u20102.50,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010trend\u2009=\u20090.06). Associations between weight change, BMI and lethal prostate cancer were stronger for men with BMI\u2009\u2265\u200925 at age 21 compared to those with BMI\u2009&lt;\u200925. Weight change and obesity were not associated with an increased risk of biochemical recurrence. Our findings among never smoker men diagnosed with localized prostate cancer suggest a positive association between long\u2010term weight gain and risk of lethal prostate cancer. Metabolic changes associated with weight gain may promote prostate cancer progression.\n                  <\/jats:p>","DOI":"10.1002\/ijc.30803","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T20:49:53Z","timestamp":1495572593000},"page":"933-944","source":"Crossref","is-referenced-by-count":56,"title":["Weight change, obesity and risk of prostate cancer progression among men with clinically localized prostate cancer"],"prefix":"10.1002","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2843-687X","authenticated-orcid":false,"given":"Barbra A.","family":"Dickerman","sequence":"first","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas U.","family":"Ahearn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Giovannucci","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA"},{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health Boston MA"},{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meir J.","family":"Stampfer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA"},{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health Boston MA"},{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Dana Farber\/Brigham and Women's Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorelei A.","family":"Mucci","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA"},{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA"},{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.2014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/jnci\/djv088","article-title":"Adult weight gain and adiposity\u2010related cancers: a dose\u2010response meta\u2010analysis of prospective observational studies","volume":"107","author":"Keum N","year":"2015","journal-title":"J Natl Cancer 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