{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:06:04Z","timestamp":1740103564512,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES011740","CA131274"],"award-info":[{"award-number":["ES011740","CA131274"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>The incidence of squamous cell carcinoma of the oropharynx (SCCOP) continues to rise because of increasing rates of human papillomavirus (HPV) infection. Inherited polymorphisms in DNA repair pathways may influence the risk of SCCOP development and the prognosis of SCCOP. We sought to determine whether polymorphisms in microRNA (miRNA)\u2010binding sites within 3\u2032\u2010untranslated regions (3'UTRs) of genes in DNA repair pathways modulate the risk of SCCOP recurrence. We evaluated the associations between nine such polymorphisms and SCCOP recurrence in 1,008 patients with incident SCCOP using the log\u2010rank test and multivariable Cox models. In an analysis of all the patients, patients with variant genotypes of <jats:italic>BRCA1<\/jats:italic> rs12516 and <jats:italic>RAD51<\/jats:italic> rs7180135 had better disease\u2010free survival (log\u2010rank, <jats:italic>p<\/jats:italic>\u2009=\u20090.0002 and <jats:italic>p<\/jats:italic>\u2009=\u20090.0003, respectively) and lower risk of SCCOP recurrence (hazard ratio [HR], 0.5, 95% confidence interval [CI], 0.2\u20130.8, and HR, 0.5, 95% CI, 0.3\u20130.9, respectively) than patients with common homozygous genotypes of the two polymorphisms after multivariable adjustment. Moreover, in tumor HPV16\u2010positive patients, patients with variant genotypes of the same two polymorphisms also had better disease\u2010free survival (log\u2010rank, <jats:italic>p<\/jats:italic>\u2009=\u20090.004 and <jats:italic>p<\/jats:italic>\u2009=\u20090.003, respectively) and lower recurrence risk (HR, 0.2, 95% CI, 0.1\u20130.6, and HR, 0.2, 95% CI, 0.0\u20130.7, respectively) than patients with common homozygous genotypes of the two polymorphisms. No such significant associations were found for other polymorphisms. These findings support significant roles of <jats:italic>BRCA1<\/jats:italic> rs12516 and <jats:italic>RAD51<\/jats:italic> rs7180135 in modifying the risk of recurrence of SCCOP, particularly HPV16\u2010positive SCCOP. However, these results must be validated in larger studies.<\/jats:p>","DOI":"10.1002\/ijc.30849","type":"journal-article","created":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T08:34:42Z","timestamp":1498293282000},"page":"1355-1364","source":"Crossref","is-referenced-by-count":9,"title":["Genetic variants in microRNA\u2010binding sites of DNA repair genes as predictors of recurrence in patients with squamous cell carcinoma of the oropharynx"],"prefix":"10.1002","volume":"141","author":[{"given":"Lijun","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX"},{"name":"Department of Oral and Maxillofacial Surgery Guangdong General Hospital &amp; Guangdong Academy of Medical Sciences Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich M.","family":"Sturgis","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX"},{"name":"Department of Epidemiology The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Yuhuangding Hospital of Qingdao University Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Guangdong General Hospital and Guangdong Academy of Medical Sciences Guangzhou Guangdong 510080 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