{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:50:36Z","timestamp":1790272236024,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50CA090388, R01DA011386, R03CA077954, T32CA009142, U01CA096134, R21ES011667"],"award-info":[{"award-number":["P50CA090388, R01DA011386, R03CA077954, T32CA009142, U01CA096134, R21ES011667"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007185","name":"University of California, Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>The possible role of dietary fiber in the etiology of head neck cancers (HNCs) is unclear. We used individual\u2010level pooled data from ten case\u2010control studies (5959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, to examine the association between fiber intake and cancer of the oral cavity\/pharynx and larynx. Odds Ratios (ORs) and their 95% Confidence Intervals (CIs) were estimated using unconditional multiple logistic regression applied to quintile categories of non\u2010alcohol energy\u2010adjusted fiber intake and adjusted for tobacco and alcohol use and other known or putative confounders. Fiber intake was inversely associated with oral and pharyngeal cancer combined (OR for 5th <jats:italic>vs<\/jats:italic>. 1st quintile category\u2009=\u20090.49, 95% CI: 0.40\u20130.59; <jats:italic>p<\/jats:italic> for trend &lt;0.001) and with laryngeal cancer (OR\u2009=\u20090.66, 95% CI: 0.54\u20130.82, <jats:italic>p<\/jats:italic> for trend &lt;0.001). There was, however, appreciable heterogeneity of the estimated effect across studies for oral and pharyngeal cancer combined. Nonetheless, inverse associations were consistently observed for the subsites of oral and pharyngeal cancers and within most strata of the considered covariates, for both cancer sites. Our findings from a multicenter large\u2010scale pooled analysis suggest that, although in the presence of between\u2010study heterogeneity, a greater intake of fiber may lower HNC risk.<\/jats:p>","DOI":"10.1002\/ijc.30886","type":"journal-article","created":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T01:56:44Z","timestamp":1500083804000},"page":"1811-1821","source":"Crossref","is-referenced-by-count":35,"title":["Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium"],"prefix":"10.1002","volume":"141","author":[{"given":"Daisuke","family":"Kawakita","sequence":"first","affiliation":[{"name":"Branch of Medical Statistics, Biometry and Epidemiology\u2033 G. A. Maccacaro\u2033 Department of Clinical Sciences and Community Health, Universit\u00e0 degli Studi di Milano Milano 20133 Italy"},{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences Nagoya 467\u20100001 Japan"},{"name":"Division of Molecular and Clinical Epidemiology Aichi Cancer Center Research Institute Nagoya 464\u20108681 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Chin Amy","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Public Health Department of Family &amp; Preventive Medicine and Huntsman Cancer Institute, University of Utah School of Medicine Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5841-5773","authenticated-orcid":false,"given":"Federica","family":"Turati","sequence":"additional","affiliation":[{"name":"Branch of Medical Statistics, Biometry and Epidemiology\u2033 G. 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