{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:33:03Z","timestamp":1790400783488,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Fondazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/75918\/2011"],"award-info":[{"award-number":["SFRH\/BPD\/75918\/2011"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,11,15]]},"abstract":"<jats:p>An association between heavy alcohol drinking and gastric cancer risk has been recently reported, but the issue is still open to discussion and quantification. We investigated the role of alcohol drinking on gastric cancer risk in the \u201cStomach cancer Pooling (StoP) Project,\u201d a consortium of epidemiological studies. A total of 9,669 cases and 25,336 controls from 20 studies from Europe, Asia and North America were included. We estimated summary odds\u2010ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study\u2010specific ORs using random\u2010effects meta\u2010regression models. Compared with abstainers, drinkers of up to 4 drinks\/day of alcohol had no increase in gastric cancer risk, while the ORs were 1.26 (95% CI, 1.08\u20131.48) for heavy (&gt;4 to 6 drinks\/day) and 1.48 (95% CI 1.29\u20131.70) for very heavy (&gt;6 drinks\/day) drinkers. The risk for drinkers of &gt;4 drinks\/day was higher in never smokers (OR 1.87, 95% CI 1.35\u20132.58) as compared with current smokers (OR 1.14, 95% CI 0.93\u20131.40). Somewhat stronger associations emerged with heavy drinking in cardia (OR 1.61, 95% CI 1.11\u20132.34) than in non\u2010cardia (OR 1.28, 95% CI 1.13\u20131.45) gastric cancers, and in intestinal\u2010type (OR 1.54, 95% CI 1.20\u20131.97) than in diffuse\u2010type (OR 1.29, 95% CI 1.05\u20131.58) cancers. The association was similar in strata of <jats:italic>H. pylori<\/jats:italic> infected (OR\u2009=\u20091.52, 95% CI 1.16\u20132.00) and noninfected subjects (OR\u2009=\u20091.69, 95% CI 0.95\u20133.01). Our collaborative pooled\u2010analysis provides definite, more precise quantitative evidence than previously available of an association between heavy alcohol drinking and gastric cancer risk.<\/jats:p>","DOI":"10.1002\/ijc.30891","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T12:49:05Z","timestamp":1500382145000},"page":"1950-1962","source":"Crossref","is-referenced-by-count":106,"title":["Alcohol consumption and gastric cancer risk\u2014A pooled analysis within the StoP project consortium"],"prefix":"10.1002","volume":"141","author":[{"given":"Matteo","family":"Rota","sequence":"first","affiliation":[{"name":"Department of Epidemiology IRCCS \u2010 Istituto di Ricerche Farmacologiche Mario Negri Milan Italy"},{"name":"Department of Biomedical and Clinical Sciences University of Milan  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