{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:54:15Z","timestamp":1782896055602,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 105\u20102314\u2010B\u2010037\u2010019\u2010MY3"],"award-info":[{"award-number":["MOST 105\u20102314\u2010B\u2010037\u2010019\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,11,15]]},"abstract":"<jats:p>Esophageal squamous\u2010cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head\u2010and\u2010neck squamous\u2010cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. Eight hundred and fifteen incident HNSCC patients were prospectively recruited for endoscopy screening for ESCN using white\u2010light imaging, narrow\u2010band imaging, Lugol chromoendoscopy, and pathological confirmation. Associated lifestyle and clinicopathological data were collected. The interquartile follow\u2010up period cutoffs were 11.3, 20.5 and 34.9 months. 124 patients (15.2%) were diagnosed as having synchronous ESCN (66 low\u2010grade dysplasia, 29 high\u2010grade dysplasia, and 29 esophageal squamous\u2010cell carcinoma). Consumption of alcohol, but not betel nut or cigarette, was significantly associated with the presence of synchronous ESCN (adjusted odds ratio [aOR]\u2009=\u20097.1 and 10.9 for former and current drinkers, respectively). There was an interaction between cumulative dose of alcohol consumption and alcohol flushing response on the development of ESCN. High\u2010dose drinkers with flush response were 16.9 times more likely to have esophageal high\u2010grade dysplasia\/SCC than non\u2010drinkers. Compared with oral cavity cancer patients, those with hypopharyngeal, laryngeal and oropharyngeal cancer were 6.8, 4.6 and 2.8 times more likely to have esophageal high\u2010grade dysplasia\/SCC. HNSCC patients with synchronous ESCN had lower overall survival than those without (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). In conclusion, surveillance of ESCN is strongly recommended for the high\u2010risk subpopulation of HNSCC patients, especially drinkers who have a flush response to alcohol, and those with distant metastasis of index cancer and cancers in hypopharynx, oropharynx and larynx.<\/jats:p>","DOI":"10.1002\/ijc.30911","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T01:52:37Z","timestamp":1501465957000},"page":"1987-1996","source":"Crossref","is-referenced-by-count":50,"title":["Endoscopic screening for synchronous esophageal neoplasia among patients with incident head and neck cancer: Prevalence, risk factors, and outcomes"],"prefix":"10.1002","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-7542","authenticated-orcid":false,"given":"Yao\u2010Kuang","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung 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