{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:23:33Z","timestamp":1787682213503,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dr Azar-Ang\u00e9lil Research Chair in Head and Neck Oncology"},{"name":"Institut du Cancer de Montr\u00e9al"},{"name":"Fonds de Recherche du Quebec, Sant\u00e9"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>The purpose of this study was to determine the prognostic value and oncogenic pathways associated to miRNA expression in squamous cell carcinoma of the oral tongue and to link these miRNA candidates with potential gene targets. We performed a miRNA screening within our institutional cohort (<jats:italic>n<\/jats:italic>\u2009=\u200958 patients) and reported five prognostic targets including a cluster of four co\u2010expressed miRNAs (miR\u201018a, miR\u201092a, miR\u2010103, and miR\u2010205). Multivariate analysis showed that expression of miR\u2010548b (<jats:italic>p<\/jats:italic>\u2009=\u20090.007) and miR\u201018a (<jats:italic>p<\/jats:italic>\u2009=\u20090.004, representative of co\u2010expressed miRNAs) are independent prognostic markers for squamous cell carcinoma of the oral tongue. These findings were validated in The Cancer Genome Atlas (TCGA) cohort (<jats:italic>n<\/jats:italic>\u2009=\u2009131) for both miRNAs (miR\u2010548b: <jats:italic>p<\/jats:italic>\u2009=\u20090.027; miR\u201018a: <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Bioinformatics analysis identified PTEN and ACTN4 as direct targets of the four co\u2010expressed miRNAs and miR\u2010548b, respectively. Correlations between the five identified miRNAs and their respective targeted genes were validated in the two merged cohorts and were concordantly significant (miR\u201018a\/PTEN: <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001; miR\u201092a\/PTEN: <jats:italic>p<\/jats:italic>\u2009=\u20090.0008; miR\u2010103\/PTEN: <jats:italic>p<\/jats:italic>\u2009=\u20090.008; miR\u2010203\/PTEN: <jats:italic>p<\/jats:italic>\u2009=\u20090.019; miR\u2010548b\/ACTN4: <jats:italic>p<\/jats:italic>\u2009=\u20090.009).<\/jats:p>","DOI":"10.1002\/ijc.30915","type":"journal-article","created":{"date-parts":[[2017,8,5]],"date-time":"2017-08-05T03:12:42Z","timestamp":1501902762000},"page":"2318-2328","source":"Crossref","is-referenced-by-count":24,"title":["Four <scp>PTEN<\/scp>\u2010targeting co\u2010expressed mi<scp>RNA<\/scp>s and <scp>ACTN<\/scp>4\u2010 targeting mi<scp>R<\/scp>\u2010548b are independent prognostic biomarkers in human squamous cell carcinoma of the oral tongue"],"prefix":"10.1002","volume":"141","author":[{"given":"Ilyes","family":"Berania","sequence":"first","affiliation":[{"name":"CRCHUM and Institut du cancer de Montr\u00e9al Montreal QC Canada"},{"name":"Otolaryngology\u2010Head and Neck Surgery Service Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume B.","family":"Cardin","sequence":"additional","affiliation":[{"name":"CRCHUM and Institut du cancer de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Cl\u00e9ment","sequence":"additional","affiliation":[{"name":"CRCHUM and Institut du cancer de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Guertin","sequence":"additional","affiliation":[{"name":"Otolaryngology\u2010Head and Neck Surgery Service Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareck","family":"Ayad","sequence":"additional","affiliation":[{"name":"Otolaryngology\u2010Head and Neck Surgery Service Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bissada","sequence":"additional","affiliation":[{"name":"Otolaryngology\u2010Head and Neck Surgery Service Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuc Felix","family":"Nguyen\u2010Tan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Filion","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Guilmette","sequence":"additional","affiliation":[{"name":"Department of Pathology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal QC Canada"},{"name":"Department of Pathology Massachusetts General Hospital\/Massachusetts Eye and Ear Infirmary Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olguta","family":"Gologan","sequence":"additional","affiliation":[{"name":"Department of Pathology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Soulieres","sequence":"additional","affiliation":[{"name":"Department of Medicine, Service of Hemato\u2010Oncology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Rodier","sequence":"additional","affiliation":[{"name":"CRCHUM and Institut du cancer de Montr\u00e9al Montreal QC Canada"},{"name":"D\u00e9partement de radiologie, radio\u2010oncologie et medicine nucl\u00e9aire Universit\u00e9 de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Wong","sequence":"additional","affiliation":[{"name":"CRCHUM and Institut du cancer de Montr\u00e9al Montreal QC Canada"},{"name":"Department of Radiation Oncology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8491-9289","authenticated-orcid":false,"given":"Apostolos","family":"Christopoulos","sequence":"additional","affiliation":[{"name":"CRCHUM and Institut du cancer de Montr\u00e9al Montreal QC Canada"},{"name":"Otolaryngology\u2010Head and Neck Surgery Service Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197206)29:6<1446::AID-CNCR2820290604>3.0.CO;2-C"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80333-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2001.0382"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01861.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.07.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.7883"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20998"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23807"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-11"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.12"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3932"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/EdBook_AM.2013.33.e395"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109653"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009290"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066838"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.04.012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1593\/tlo.09277"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2648"},{"key":"e_1_2_7_21_1","first-page":"30064","article-title":"Buparlisib and paclitaxel in patients with platinum\u2010pretreated recurrent or metastatic squamous cell carcinoma of the head and neck (BERIL\u20101): a randomized, double\u2010blind, placebo\u2010controlled phase 2 trial","volume":"17","author":"Soulieres D","year":"2017","journal-title":"Lancet Oncol"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-014-0231-0"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0170"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.03.010"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0095"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004088"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131024"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1985-8"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2011.05.002"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3485"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.294"},{"key":"e_1_2_7_32_1","first-page":"3579","article-title":"MicroRNA\u201092a promotes metastasis of nasopharyngeal carcinoma by targeting the PTEN\/AKT pathway","volume":"9","author":"Zhang H","year":"2016","journal-title":"Onco Targets Ther"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2013.125"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.10.042"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.05.017"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-0667"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.4236\/alc.2014.32007"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.186"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.12.1441"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(99)01519-6"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12634"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15058458"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.449025"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2755"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.11.4.19228"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-0297"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606917103"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2009.10.003"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802656"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602252"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.11.014"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.30915","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.30915","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.30915","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.30915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T05:16:30Z","timestamp":1694668590000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.30915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,18]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/ijc.30915"],"URL":"https:\/\/doi.org\/10.1002\/ijc.30915","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,18]]}}}