{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:45:00Z","timestamp":1768319100126,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mermaid Project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Antidepressants are widely prescribed among women to treat depression and anxiety disorders, but studies of their effects on gynecological cancer risk are sparse. We assessed associations between various antidepressants and risk of epithelial ovarian cancer. By using Danish nationwide registers, we identified all women (cases) aged 30\u201384 years with incident epithelial (serous, endometrioid, clear cell or mucinous) ovarian cancer during 2000\u20132011 (<jats:italic>n<\/jats:italic>\u2009=\u20094,103) and matched each case to 20 population controls (<jats:italic>n<\/jats:italic>\u2009=\u200958,706) by risk\u2010set matching. Data on drug use (including tricyclic and related antidepressants, selective serotonin reuptake inhibitors, other antidepressants, and potential confounder drugs), medical and reproductive history and socioeconomic parameters, were obtained from nationwide registries. We used conditional logistic regression models to estimate adjusted odds ratios (ORs) and two\u2010sided 95% confidence intervals (CIs) for epithelial ovarian cancer associated with antidepressive drug use. Compared with non\u2010use, use of selective serotonin reuptake inhibitors was associated with a decreased risk of ovarian cancer (OR, 0.85; 95% CI, 0.74\u20130.96), whereas the associations for other antidepressants were close to unity [tricyclic and related antidepressants: OR, 0.99 (95% CI, 0.78\u20131.26); other antidepressants: OR, 1.05 (95% CI, 0.76\u20131.46)]. For individual types of SSRI, reduced ORs were observed for citalopram OR, 0.78 (95% CI, 0.66\u20130.93), paroxetine 0.79 (95% CI, 0.56\u20131.12) and sertraline 0.80 (95% CI, 0.60\u20131.08). Among postmenopausal women, the inverse association was restricted to users of menopausal hormone therapy. In conclusion, use of selective serotonin reuptake inhibitors was associated with a decreased risk of epithelial ovarian cancer; thereby implying potential chemopreventive properties of these drugs.<\/jats:p>","DOI":"10.1002\/ijc.30919","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T08:48:42Z","timestamp":1502268522000},"page":"2197-2203","source":"Crossref","is-referenced-by-count":36,"title":["Use of antidepressants and risk of epithelial ovarian cancer"],"prefix":"10.1002","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6506-2569","authenticated-orcid":false,"given":"Lina S.","family":"M\u00f8rch","sequence":"first","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center, DK\u20102100 Copenhagen Denmark"},{"name":"Department of Gynecology, Rigshospitalet University of Copenhagen, DK\u20102100 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Dehlendorff","sequence":"additional","affiliation":[{"name":"Unit of Statistics and Pharmacoepidemiology Danish Cancer Society Research Center, DK\u20102100 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Baandrup","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center, DK\u20102100 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Friis","sequence":"additional","affiliation":[{"name":"Unit of Statistics and Pharmacoepidemiology Danish Cancer Society Research Center, DK\u20102100 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne K.","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center, DK\u20102100 Copenhagen Denmark"},{"name":"Department of Gynecology, Rigshospitalet University of Copenhagen, DK\u20102100 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"American Cancer Society.2013(Available at:http:\/\/www.cancer.org\/acs\/groups\/content\/@epidemiologysurveilance\/documents\/document\/acspc\u2010036845.pdf"},{"key":"e_1_2_7_3_1","first-page":"3796","article-title":"Stimulation of malignant growth in rodents by antidepressant drugs at clinically relevant doses","volume":"52","author":"Brandes LJ","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(93)90104-N"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018210"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n1003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.01.020"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00052773"},{"key":"e_1_2_7_9_1","first-page":"697","article-title":"Psychotropic medication use and risk of epithelial ovarian cancer","volume":"7","author":"Harlow BL","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_7_10_1","first-page":"830","article-title":"Risk of ovarian cancer according to use of antidepressants, phenothiazines, and benzodiazepines (United States)","volume":"11","author":"Coogan PF","year":"2000","journal-title":"Cancer Causes Control"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013969611593"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000157113.98061.eb"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3700"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00092-0"},{"key":"e_1_2_7_15_1","unstructured":"National Institute for Clinical Excellence. 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