{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:06:16Z","timestamp":1740103576316,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T00:00:00Z","timestamp":1503532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["CAN 2010\/225","CAN 2011\/883"],"award-info":[{"award-number":["CAN 2010\/225","CAN 2011\/883"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Outcome data comparing patients with multiple primary invasive cutaneous malignant melanomas (MPMs) to single primary invasive cutaneous malignant melanomas (SPMs) show conflicting results. We have analyzed differences in disease\u2010specific survival between these patients in a nationwide population\u2010based setting. From the Swedish Melanoma Register, 27,235 patients were identified with a first invasive cutaneous malignant melanoma (CMM) between 1990 and 2007, followed\u2010up through 2013. Of these, 700 patients developed MPMs. Cox proportional hazard regression was used for adjusted cause\u2010specific hazard ratios (HRs). An interval of \u22645 years between CMM diagnoses was significantly correlated to a decreased CMM\u2010specific survival in Stage I\u2013II MPM\u2010 vs. SPM\u2010patients (HR 1.32; 95% CI 1.04\u20131.67; <jats:italic>p<\/jats:italic>\u2009=\u20090.02). MPM\u2010patients with longer time interval between diagnoses experienced similar risk of CMM\u2010death as SPM\u2010patients. The risk of CMM\u2010death increased by almost 50% above the expected outcome according to stage of the index CMM by the diagnosis of a second CMM (HR 1.48; 95% CI 1.19\u20131.85; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). MPM vs. SPM\u2010patients had a worse outcome (HR 1.38; 95% CI 1.05\u20131.83; <jats:italic>p<\/jats:italic>\u2009=\u20090.001). This emphasizes the importance of prevention efforts in SPM\u2010patients to decrease the risk of subsequent CMMs and has implications for more vigilant follow\u2010up in MPM\u2010patients.<\/jats:p>","DOI":"10.1002\/ijc.30925","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T08:36:43Z","timestamp":1502440603000},"page":"2243-2252","source":"Crossref","is-referenced-by-count":12,"title":["Reduced disease\u2010specific survival following a diagnosis of multiple primary cutaneous malignant melanomas\u2014a nationwide, population\u2010based study"],"prefix":"10.1002","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7335-8017","authenticated-orcid":false,"given":"Deborah","family":"Utj\u00e9s","sequence":"first","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet Stockholm Sweden"},{"name":"Department of Oncology Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Lyth","sequence":"additional","affiliation":[{"name":"Research and Development Unit in Region \u00d6sterg\u00f6tland and Department of Medical and Health Sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Lapins","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet Stockholm Sweden"},{"name":"Department of Oncology Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,24]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"FerlayJSI ErvikM DikshitR et al. 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