{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:34:50Z","timestamp":1777109690801,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:00:00Z","timestamp":1504828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2017,12,15]]},"abstract":"<jats:p>The current study aims to provide stronger evidence to aid in our understanding of the role of cumulative occupational exposure to (softwood\u2010dominated) mixed wood dust in aetiology of nasal cancer. We included broad exposure occurred in a range of wood\u2010processing occupation across varied industries in four Nordic countries. A population\u2010based case\u2010control study was conducted on all male cases with nasal adenocarcinoma (393 cases), other types of nasal cancer (2,446) and nasopharyngeal cancer (1,747) diagnosed in Finland, Sweden, Norway and Iceland between 1961 and 2005. For each case, five male controls, who were alive at the time of diagnosis of the case (index date), were randomly selected, matched by birth\u2010year and country. Cumulative exposures (CE)s to wood dust and formaldehyde before the index date were quantified based on a job\u2010exposure matrix linked to occupational titles derived from population censuses. Hazard ratios (HRs) for the CE of wood dust were estimated by conditional logistic regression, adjusted for CE to formaldehyde and 95% confidence intervals (CIs) were calculated. There was an increasing risk of nasal adenocarcinoma related to wood dust exposure. The HR in the highest CE category of wood dust (\u2265 28.82 mg\/m<jats:sup>3<\/jats:sup>\u2010years) was 16.5 (95% CI 5.05\u201354.1). Neither nonadenocarcinoma of the nose nor nasopharyngeal cancer could be linked to wood dust exposure. CE to softwood\u2010dominated mixed wood dusts is strongly linked with elevated risk in nasal adenocarcinoma but not with other types of nasal or nasopharyngeal cancer.<\/jats:p>","DOI":"10.1002\/ijc.31015","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T08:16:38Z","timestamp":1503648998000},"page":"2430-2436","source":"Crossref","is-referenced-by-count":29,"title":["Occupational exposure to wood dust and risk of nasal and nasopharyngeal cancer: A case\u2010control study among men in four nordic countries\u2014With an emphasis on nasal adenocarcinoma"],"prefix":"10.1002","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4309-9501","authenticated-orcid":false,"given":"Sie Sie","family":"Siew","sequence":"first","affiliation":[{"name":"Faculty of Social Sciences University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Ivar","family":"Martinsen","sequence":"additional","affiliation":[{"name":"Cancer Registry of Norway Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Kjaerheim","sequence":"additional","affiliation":[{"name":"Cancer Registry of Norway Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4r","family":"Spar\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laufey","family":"Tryggvadottir","sequence":"additional","affiliation":[{"name":"Icelandic Cancer Registry, Reykjavik, Iceland"},{"name":"Faculty of Medicine, University of Iceland Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabete","family":"Weiderpass","sequence":"additional","affiliation":[{"name":"Cancer Registry of Norway, Institute of Population\u2010Based Cancer Research, Oslo, Norway"},{"name":"Department of Community Medicine Faculty of Health Sciences, University of Troms\u00f8, The Arctic University of Norway, Troms\u00f8, Norway"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm, Sweden"},{"name":"Genetic Epidemiology Group, Folkh\u00e4lsan Research Center Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eero","family":"Pukkala","sequence":"additional","affiliation":[{"name":"Director for Research, Finnish Cancer Registry\u2014Institute for Statistical and Epidemiological Cancer Research, Unioninkatu 22, FI\u201000130 Helsinki, Finland"},{"name":"Professor in Epidemiology, Faculty of Social Sciences, University of Tampere  Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5605.587"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Wood dust and formaldehyde","volume":"62","author":"International Agency for Research on Cancer","year":"1995","journal-title":"IARC Monogr Eval Carcinog Risk Chem Hum"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/mel013"},{"key":"e_1_2_7_5_1","first-page":"1","article-title":"Wood, leather and some associated industries","volume":"25","author":"International Agency for Research on Cancer","year":"1981","journal-title":"IARC Monogr Eval Carcinog Risk Chem Hum"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"Overall evaluations of carcinogenicity: an updating of IARC Monographs volumes 1 to 42","volume":"7","author":"International Agency for Research on Cancer","year":"1987","journal-title":"IARC Monogr Eval Carcinog Risks Hum Suppl"},{"key":"e_1_2_7_7_1","first-page":"407","article-title":"Arsenic, metals, fibres, and dusts. 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