{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:15:29Z","timestamp":1792196129131,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01 HL128791, P01 CA87969, R01 CA047988, R01 HL043851, R01 HL080467, RC1 HL099355, T32 CA09001, UM1 CA176726, UM1 CA182913"],"award-info":[{"award-number":["K01 HL128791, P01 CA87969, R01 CA047988, R01 HL043851, R01 HL080467, RC1 HL099355, T32 CA09001, UM1 CA176726, UM1 CA182913"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Migraine is a common primary headache disorder, which predominantly impacts women. Recently, migraine has been hypothesized to be associated with hormonally related cancers; however, the potential association between migraine and ovarian cancer has not been studied. Therefore, we evaluated the association between migraine and invasive epithelial ovarian cancer risk in two prospective cohorts, the Nurses\u2019 Health Study II (NHSII) and the Women's Health Study (WHS). Our prospective analysis included 113,124 NHSII participants aged 25\u201342 at study baseline as well as 33,490 participants in the WHS who were 45 years or older at study entry. We used Cox proportional hazards models to estimate the hazard ratios (HR) and 95% confidence intervals (CIs) for the association between migraine and ovarian cancer risk in each cohort. In secondary analyses, we stratified by age and menopausal status. After adjusting for potential covariates, there was no statistically significant association between migraine and ovarian cancer risk in either the NHSII (HR\u2009=\u20091.29, 95%CI: 0.96, 1.74) or the WHS (HR\u2009=\u20090.60, 95%CI: 0.34, 1.06). In stratified analysis in the NHSII, there was a statistically significant positive association between migraine and ovarian cancer risk among women &lt;45 years of age (HR\u2009=\u20091.76, 95%CI: 1.01, 3.07). We did not observe a clear association between migraine and ovarian cancer risk in two large prospective cohort studies.<\/jats:p>","DOI":"10.1002\/ijc.31062","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T08:12:44Z","timestamp":1505895164000},"page":"534-539","source":"Crossref","is-referenced-by-count":7,"title":["Migraine and invasive epithelial ovarian cancer risk in the Nurses\u2019 Health Study II and the Women's Health Study"],"prefix":"10.1002","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8900-4889","authenticated-orcid":false,"given":"Megan S.","family":"Rice","sequence":"first","affiliation":[{"name":"Clinical and Translational Epidemiology Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela M.","family":"Rist","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, Department of Medicine Brigham and Women's Hospital, Harvard Medical School Boston MA"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke C.","family":"Winter","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Department of Surgery Washington University School of Medicine St. Louis MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Kurth","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, Department of Medicine Brigham and Women's Hospital, Harvard Medical School Boston MA"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA"},{"name":"Institute of Public Health, Charit\u00e9 Universit\u00e4tsmedizin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley S.","family":"Tworoger","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA"},{"name":"Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2008.11.011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.15.1824"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)91558-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1986.0601043.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1990.1003147.x"},{"key":"e_1_2_6_7_1","first-page":"69","article-title":"Plasma met\u2010enkephalin and catecholamine changes during the menstrual cycle and pain episode in menstrual migraine","volume":"12","author":"Lourdes Figuerola M","year":"1997","journal-title":"Funct Neurol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-006-0274-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju381"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14943"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0291"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.0423"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0527"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-012-0092-x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-006360"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01835.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532940"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp314"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.8178"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.3.283"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i2610"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.3.537"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2001.041007646.x"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.31062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.31062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T02:09:25Z","timestamp":1696039765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.31062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,30]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/ijc.31062"],"URL":"https:\/\/doi.org\/10.1002\/ijc.31062","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,30]]}}}