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However, it is unknown whether radiation\u2010specific molecular oncogenic mechanisms exist. We investigated post\u2010Chernobyl breast cancers from radiation\u2010exposed female clean\u2010up workers and nonexposed controls for molecular changes. Radiation\u2010associated alterations identified in the discovery cohort (<jats:italic>n<\/jats:italic>\u2009=\u200938) were subsequently validated in a second cohort (<jats:italic>n<\/jats:italic>\u2009=\u200939). Increased expression of hsa\u2010miR\u201026b\u20105p was associated with radiation exposure in both of the cohorts. Moreover, downregulation of the TRPS1 protein, which is a transcriptional target of hsa\u2010miR\u201026b\u20105p, was associated with radiation exposure. As TRPS1 overexpression is common in sporadic breast cancer, its observed downregulation in radiation\u2010associated breast cancer warrants clarification of the specific functional role of TRPS1 in the radiation context. For this purpose, the impact of TRPS1 on the transcriptome was characterized in two radiation\u2010transformed breast cell culture models after siRNA\u2010knockdown. Deregulated genes upon TRPS1 knockdown were associated with DNA\u2010repair, cell cycle, mitosis, cell migration, angiogenesis and EMT pathways. Furthermore, we identified the interaction partners of TRPS1 from the transcriptomic correlation networks derived from gene expression data on radiation\u2010transformed breast cell culture models and sporadic breast cancer tissues provided by the TCGA database. The genes correlating with TRPS1 in the radiation\u2010transformed breast cell lines were primarily linked to DNA damage response and chromosome segregation, while the transcriptional interaction partners in the sporadic breast cancers were mostly associated with apoptosis. Thus, upregulation of hsa\u2010miR\u201026b\u20105p and downregulation of TRPS1 in radiation\u2010associated breast cancer tissue samples suggests these molecules representing radiation markers in breast cancer.<\/jats:p>","DOI":"10.1002\/ijc.31072","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T08:31:02Z","timestamp":1506328262000},"page":"573-583","source":"Crossref","is-referenced-by-count":33,"title":["Expression of mi<scp>RNA<\/scp>\u201026b\u20105p and its target <scp>TRPS<\/scp>1 is associated with radiation exposure in post\u2010<scp>C<\/scp>hernobyl breast cancer"],"prefix":"10.1002","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-4033","authenticated-orcid":false,"given":"Christina M.","family":"Wilke","sequence":"first","affiliation":[{"name":"Research Unit Radiation Cytogenetics, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH Neuherberg 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