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We conducted a case\u2013control study in a county located at Southeastern China, including 46 cases and 230 individually matched controls. A semi\u2010quantitative method based on experts' assessment was used for evaluating hand\u2010spinning chrysotile exposure. Conditional logistic regression models were used to assess the association of asbestos exposure with risk of mesothelioma. We found that hand\u2010spinning chrysotile exposure was associated with significantly elevated risk of mesothelioma, reaching OR =10 (95% CIs: 1.4\u201365) for possible exposure and 64 (12\u2013328) for definite exposure. Our data suggested a dose\u2013response relationship of chrysotile exposure duration with risk of mesothelioma, reaching 28 (6\u2013134) for &lt;6 years, 51 (11\u2013247) for 7\u201317 years and 56 (9\u2013351) for \u226518 years. A dose\u2013response relationship of cumulative exposure index (CEI) with risk of mesothelioma was found, reaching 28 (6\u2013137) for CEI at 0\u20130.5 fibers per milliliter years (f\/mL\u2010year), 36 (7\u2013184) for CEI at 0.5\u201328.6 f\/mL\u2010years and 79 (14\u2013451) for CEI\u2009&gt;\u200928.6 f\/mL\u2010years. We found a dose\u2013response relationship of chrysotile exposure duration and CEI with risk of mesothelioma in Southeastern China, adding valuable information on health hazards of chrysotile exposure in China where chrysotile is still used nationwide.<\/jats:p>","DOI":"10.1002\/ijc.31077","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T08:49:02Z","timestamp":1506415742000},"page":"514-523","source":"Crossref","is-referenced-by-count":28,"title":["Hand\u2010spinning chrysotile exposure and risk of malignant mesothelioma: A case\u2013control study in <scp>S<\/scp>outheastern <scp>C<\/scp>hina"],"prefix":"10.1002","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9690-376X","authenticated-orcid":false,"given":"Zhaoqiang","family":"Jiang","sequence":"first","affiliation":[{"name":"Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences Hangzhou Zhejiang Province 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