{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:23:50Z","timestamp":1772796230179,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011201","name":"FP7 Science in Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011201","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,2]]},"abstract":"The clinical value of sentinel lymph node (SLN) biopsy in thick melanoma patients (Breslow >4 mm) has not been sufficiently studied. The aim of the study is to evaluate whether SLN biopsy increases survival in patients with thick cutaneous melanoma, and, as a secondary objective, to investigate correlations between survival and lymph node status. We included 1,211 consecutive patients with thick melanomas (>4 mm) registered in the participating hospitals' melanoma databases between 1997 and 2015. Median follow\u2010up was 40 months. Of these patients, 752 were matched into pairs by propensity scores based on sex, age, tumor location, histologic features of melanoma, year of diagnosis, hospital and adjuvant interferon therapy. The SLN biopsy vs<\/jats:italic>. observation was associated with better DFS [adjusted hazard ratio (AHR), 0.74; 95% confidence interval (CI) 0.61\u20130.90); p<\/jats:italic>\u2009=\u20090.002] and OS (AHR, 0.75; 95% CI, 0.60\u20130.94; p<\/jats:italic>\u2009=\u20090.013) but not MSS (AHR, 0.84; 95% CI, 0.65\u20131.08; p<\/jats:italic>\u2009=\u20090.165). SLN\u2010negative patients had better 5\u2010 and 10\u2010year MSS compared with SLN\u2010positive patients (65.4 vs<\/jats:italic>. 51.9% and 48.3 vs<\/jats:italic>. 38.8%; p<\/jats:italic>\u2009=\u20090.01, respectively). As a conclusion, SLN biopsy was associated with better DFS but not MSS in thick melanoma patients after adjustment for classic prognostic factors. SLN biopsy is useful for stratifying these patients into different prognostic groups.<\/jats:p>","DOI":"10.1002\/ijc.31078","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T09:57:56Z","timestamp":1506506276000},"page":"641-648","source":"Crossref","is-referenced-by-count":20,"title":["Sentinel lymph node biopsy versus observation in thick melanoma: A multicenter propensity score matching study"],"prefix":"10.1002","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9809-5308","authenticated-orcid":false,"given":"Aram","family":"Boada","sequence":"first","affiliation":[{"name":"Dermatology Department Hospital Universitari Germans Trial i Pujol, Badalona, Universitat Aut\u00f2noma de Barcelona 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(IDIBAPS) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER) de Enfermedades Raras Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Moreno\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Medical\u2010&\u2010Surgical Dermatology Department Hospital Universitario Virgen Macarena Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2262-7547","authenticated-orcid":false,"given":"Miguel A.","family":"Descalzo\u2010Gallego","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Fundaci\u00f3n Piel Sana, Academia Espa\u00f1ola de Dermatolog\u00eda Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-6322","authenticated-orcid":false,"given":"Mar\u00eda T.","family":"Fierro","sequence":"additional","affiliation":[{"name":"Medical Sciences 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