{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:01:10Z","timestamp":1787770870765,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:00:00Z","timestamp":1510617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,2,15]]},"abstract":"<jats:p>Myoepithelial tumors of the soft tissue are a rare tumor displaying myoepithelial elements and lacking obvious ductal differentiation. The rarity of these precludes any evidence\u2010based consensus regarding optimal management. Nevertheless, the current approach to these lesions begins with amputation or complete excision. The efficacy of neoadjuvant or adjuvant radiation therapy or chemotherapy has not been established. Here, we present the first report to the authors\u2019 knowledge of neoadjuvant radiation therapy for the treatment of this rare soft tissue neoplasm and review the management and outcomes of published cases of myoepithelial carcinoma. A patient with a soft tissue myoepithelial carcinoma that declined both amputation and chemotherapy was treated with neoadjuvant radiation therapy and wide surgical excision followed by a brachytherapy boost to the resected tumor bed. Neoadjuvant radiation therapy resulted in an excellent response with extensive treatment\u2010related changes consisting predominantly of fibrosis, hyalinization and hemorrhage and only 10% residual viable myoepithelial carcinoma present in the surgical specimen.<\/jats:p>","DOI":"10.1002\/ijc.31101","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T08:36:37Z","timestamp":1507797397000},"page":"854-862","source":"Crossref","is-referenced-by-count":13,"title":["Neoadjuvant radiation therapy for the management of myoepithelial carcinoma of the upper extremity"],"prefix":"10.1002","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7835-718X","authenticated-orcid":false,"given":"Rafi","family":"Kabarriti","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Albert\u2010Einstein College of Medicine\u2010Montefiore Medical Center Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas 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