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In our study, we explored the role of SOX8 and its molecular mechanism in the regulation of the stemness properties and the epithelial mesenchymal transition (EMT) of cisplatin\u2010resistant tongue squamous cell carcinoma (TSCC) cells. We found that SOX8 was upregulated in cisplatin\u2010resistant TSCC cells, which displayed CSC\u2010like properties and exhibited EMT. SOX8 was also overexpressed in chemoresistant patients with TSCC and was associated with higher lymph node metastasis, advanced tumor stage and shorter overall survival. Stable knockdown of SOX8 in cisplatin\u2010resistant TSCC cells inhibited chemoresistance, tumorsphere formation, and EMT. The Wnt\/\u03b2\u2010catenin pathway mediated the cancer stem\u2010like properties in cisplatin\u2010resistant TSCC cells. Further studies showed that the transfection of active \u03b2\u2010catenin in SOX8 stable\u2010knockdown cells partly rescued the SOX8 silencing\u2010induced repression of stem\u2010like features and chemoresistance. Through chromatin immunoprecipitation and luciferase assays, we observed that SOX8 bound to the promoter region of Frizzled\u20107 (FZD7) and induced the FZD7\u2010mediated activation of the Wnt\/\u03b2\u2010catenin pathway. In summary, SOX8 confers chemoresistance and stemness properties and mediates EMT processes in chemoresistant TSCC via the FZD7\u2010mediated Wnt\/\u03b2\u2010catenin pathway.<\/jats:p>","DOI":"10.1002\/ijc.31134","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T03:56:37Z","timestamp":1508990197000},"page":"1252-1265","source":"Crossref","is-referenced-by-count":117,"title":["SOX8 regulates cancer stem\u2010like properties and cisplatin\u2010induced EMT in tongue squamous cell carcinoma by acting on the Wnt\/\u03b2\u2010catenin pathway"],"prefix":"10.1002","volume":"142","author":[{"given":"S.\u2010L.","family":"Xie","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University Guangzhou China"},{"name":"Department of Oral &amp; Maxillofacial Surgery Sun Yat\u2010sen Memorial Hospital, Sun Yat\u2010sen University 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