{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:10:18Z","timestamp":1767136218811,"version":"build-2238731810"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,3,15]]},"abstract":"<jats:p>\n                    Platinum\u2010based chemotherapy (PBC) in combination with the 3\n                    <jats:sup>rd<\/jats:sup>\n                    generation drugs is the first\u2010line treatment for patients with advanced non\u2010small cell lung cancer (NSCLC); however, the efficacy is severely hampered by grade 3\u20134 toxicities. Nucleotide excision repair (NER) pathway is the main mechanism of removing platinum\u2010induced DNA adducts that contribute to the toxicity and outcome of PBC. We analyzed data from 710 Chinese NSCLC patients treated with PBC and assessed the associations of 25 potentially functional single nucleotide polymorphisms (SNPs) in nine NER core genes with overall, gastrointestinal and hematologic toxicities. Through a two\u2010phase study, we found that\n                    <jats:italic>ERCC4<\/jats:italic>\n                    rs1799798 was significantly associated with overall and gastrointestinal toxicities [all patients: GA\/AA vs. GG, odds ratio (OR)\n                    <jats:sub>adj<\/jats:sub>\n                    =1.61 and 2.35, 95% confidence interval (CI)=1.11\u20132.33 and 1.25\u20134.41, and\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>adj<\/jats:sub>\n                    =0.012 and 0.008, respectively]. Our prediction model for the overall toxicity incorporating rs1799798 demonstrated a significant increase in the area under the curve (AUC) value, compared to that for clinical factors only (all patients: AUC\u2009=\u20090.61 vs. 0.59, 95% CI\u2009=\u20090.57\u20130.65 vs. 0.55\u20130.63,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.010). Furthermore, the\n                    <jats:italic>ERCC4<\/jats:italic>\n                    rs1799798 A allele was associated with lower\n                    <jats:italic>ERCC4<\/jats:italic>\n                    mRNA expression levels according to the expression quantitative trait loci (eQTL) analysis. Our study provided some new clue in future development of biomarkers for assessing toxicity and outcomes of platinum drugs in lung cancer treatment.\n                  <\/jats:p>","DOI":"10.1002\/ijc.31153","type":"journal-article","created":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T03:36:41Z","timestamp":1510630601000},"page":"1218-1229","source":"Crossref","is-referenced-by-count":5,"title":["An\n                    <i>ERCC4<\/i>\n                    regulatory variant predicts grade\u20103 or \u20104 toxicities in patients with advanced non\u2010small cell lung cancer treated by platinum\u2010based therapy"],"prefix":"10.1002","volume":"142","author":[{"given":"Ruoxin","family":"Zhang","sequence":"first","affiliation":[{"name":"Cancer Institute, Collaborative Innovative Center for Cancer Medicine, Fudan University Shanghai Cancer Center, 270 Dong An Road Xuhui District Shanghai 200032 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Jia","sequence":"additional","affiliation":[{"name":"Cancer Institute, Collaborative Innovative Center for Cancer Medicine, Fudan University Shanghai Cancer Center, 270 Dong An Road Xuhui District Shanghai 200032 People's Republic of China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University Shanghai Cancer Center, 270 Dong An Road Shanghai 200032 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Cancer Institute, Collaborative Innovative Center for Cancer Medicine, Fudan University Shanghai Cancer Center, 270 Dong An Road Xuhui District Shanghai 200032 People's Republic of China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University Shanghai Cancer Center, 270 Dong An Road Shanghai 200032 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danwen","family":"Qian","sequence":"additional","affiliation":[{"name":"Cancer Institute, Collaborative Innovative Center for Cancer Medicine, Fudan University Shanghai Cancer Center, 270 Dong An Road Xuhui District Shanghai 200032 People's Republic of China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University Shanghai Cancer Center, 270 Dong An Road Shanghai 200032 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Institute, Collaborative Innovative Center for Cancer Medicine, Fudan University Shanghai Cancer Center, 270 Dong An Road Xuhui District Shanghai 200032 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Oncology Xinhua Hospital affiliated to Shanghai Jiaotong University, No. 1665 Kong Jiang Road Shanghai 200092 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menghong","family":"Sun","sequence":"additional","affiliation":[{"name":"Cancer Institute, Collaborative Innovative Center for Cancer Medicine, Fudan University Shanghai Cancer Center, 270 Dong An Road Xuhui District Shanghai 200032 People's Republic of China"},{"name":"Department of Pathology Fudan University Shanghai Cancer Center, 270 Dong An Road Shanghai 200032 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Chang","sequence":"additional","affiliation":[{"name":"Cancer Institute, Collaborative Innovative Center for Cancer Medicine, Fudan University Shanghai Cancer Center, 270 Dong An Road Xuhui District Shanghai 200032 People's Republic of China"},{"name":"Department of Medical Oncology Fudan University Shanghai Cancer Center, 270 Dong An Road Shanghai 200032 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3845-9445","authenticated-orcid":false,"given":"Qingyi","family":"Wei","sequence":"additional","affiliation":[{"name":"Cancer Institute, Collaborative Innovative Center for Cancer Medicine, Fudan University Shanghai Cancer Center, 270 Dong An Road Xuhui District Shanghai 200032 People's Republic of China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University Shanghai Cancer Center, 270 Dong An Road Shanghai 200032 People's Republic of China"},{"name":"Duke Cancer Institute, Duke University Medical Center, 10 Bryn Searle Dr. Durham NC 27710 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