{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:08Z","timestamp":1786977848457,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UK Economic and Social Research Council (ESRC) as grants to the International Centre for Life Course Studies","award":["RES-596-28-0001"],"award-info":[{"award-number":["RES-596-28-0001"]}]},{"name":"UK Economic and Social Research Council (ESRC) as grants to the International Centre for Life Course Studies","award":["ES\/JO19119\/1"],"award-info":[{"award-number":["ES\/JO19119\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,4,15]]},"abstract":"<jats:p>\n                    Accumulating evidence suggest that\n                    <jats:italic>Propionibacterium acnes<\/jats:italic>\n                    may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. The aim of this population\u2010based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an increased risk of prostate cancer later in life. We identified a large cohort of young men born in Sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the age of 18 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009243,187). Test information along with health data including medical diagnoses at time of conscription was available through the Swedish Military Conscription Register and the National Patient Register. The cohort was followed through linkages to the Swedish Cancer Register to identify the occurrence of prostate cancer until December 31, 2009. We used Cox regression to calculate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between acne in adolescence and prostate cancer risk. A total of 1,633 men were diagnosed with prostate cancer during a median follow\u2010up of 36.7 years. A diagnosis of acne was associated with a statistically significant increased risk for prostate cancer (adjusted HR: 1.43 95%; CI: 1.06\u20131.92), particularly for advanced stage disease (HR: 2.37 95%; CI 1.19\u20134.73). A diagnosis of acne classified as severe conferred a sixfold increased risk of prostate cancer (HR: 5.70 95% CI 1.42\u201322.85). Data from this large prospective population\u2010based cohort add new evidence supporting a role of\n                    <jats:italic>P. acnes<\/jats:italic>\n                    infection in prostate cancer.\n                  <\/jats:p>","DOI":"10.1002\/ijc.31192","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T05:30:21Z","timestamp":1512451821000},"page":"1580-1585","source":"Crossref","is-referenced-by-count":36,"title":["Acne in late adolescence and risk of prostate cancer"],"prefix":"10.1002","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-5300","authenticated-orcid":false,"given":"Henrik","family":"Ugge","sequence":"first","affiliation":[{"name":"Department of Urology, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruzan","family":"Udumyan","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics, School of Medical Sciences \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ove","family":"Andr\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics, School of Medical Sciences \u00d6rebro University \u00d6rebro Sweden"},{"name":"Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet Stockholm Sweden"},{"name":"Department of Epidemiology and Public Health University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Davidsson","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Fall","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics, School of Medical Sciences \u00d6rebro University \u00d6rebro Sweden"},{"name":"Department of Medical Epidemiology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04033.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2007.05.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0373"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-006-0054-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.03.029"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-016-0074-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/14796694.2.2.225"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000158161.15277.78"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23032"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi147"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2014.02.019"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2003.11.006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30471"},{"key":"e_1_2_6_16_1","unstructured":"Socialstyrelsen.The National Patient Register.http:\/\/www.socialstyrelsen.se\/register\/halsodataregister\/patientregistret\/inenglish"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802247664"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2009.100669"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-307485"},{"key":"e_1_2_6_20_1","unstructured":"Statistics Sweden: Statistics Sweden.https:\/\/www.scb.se\/sv_\/Vara-tjanster\/Bestalla-mikrodata\/"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1634008"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/81.3.515"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10810"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605757"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000136655"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/AHMT.S55832"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_6_28_1","first-page":"287","article-title":"Prevalence of acne vulgaris in Auckland senior high school students","volume":"108","author":"Lello J","year":"1995","journal-title":"N Z Med J"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04290.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.2006.01866.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.75.884.328"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-014-0099-z"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2012.01833.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-126"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2011.05.012"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90243-0"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2009.08.008"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12317162"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.22.4.232"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.07.123"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.31192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.31192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:31:14Z","timestamp":1695493874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.31192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,4,15]]}},"alternative-id":["10.1002\/ijc.31192"],"URL":"https:\/\/doi.org\/10.1002\/ijc.31192","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,14]]}}}