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However, few studies have evaluated the roles of genetic variants encoding steroid hormone receptor genes and their related regulators (SHR\u2010related genes) in CM\u2010specific survival (CMSS). Here, we performed a pathway\u2010based analysis to evaluate genetic variants of 191 SHR\u2010related genes in 858 CMSS patients using a dataset from a genome\u2010wide association study (GWAS) from The University of Texas MD Anderson Cancer Center (MDACC), and then validated the results in an additional dataset of 409 patients from the Harvard GWAS. Using multivariate Cox proportional hazards regression analysis, we identified three\u2010independent SNPs (<jats:italic>RORA<\/jats:italic> rs782917 G\u2009&gt;\u2009A, <jats:italic>RORA<\/jats:italic> rs17204952 C\u2009&gt;\u2009T and <jats:italic>DNMT1<\/jats:italic> rs7253062 G\u2009&gt;\u2009A) as predictors of CMSS, with a variant\u2010allele attributed hazards ratio (HR) and 95% confidence interval of 1.62 (1.25\u20132.09), 1.60 (1.20\u20132.13) and 1.52 (1.20\u20131.94), respectively. Combined analysis of risk genotypes of these three SNPs revealed a decreased CMSS in a dose\u2013response manner as the number of risk genotypes increased (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009&lt;\u20090.001); however, no improvement in the prediction model was observed (area under the curve [AUC]\u2009=\u200979.6\u201380.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.656), when these risk genotypes were added to the model containing clinical variables. Our findings suggest that genetic variants of <jats:italic>RORA<\/jats:italic> and <jats:italic>DNMT1<\/jats:italic> may be promising biomarkers for CMSS, but these results needed to be validated in future larger studies.<\/jats:p>","DOI":"10.1002\/ijc.31243","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T07:53:09Z","timestamp":1515052389000},"page":"2303-2312","source":"Crossref","is-referenced-by-count":16,"title":["Genetic variants in <i>RORA<\/i> and <i>DNMT1<\/i> associated with cutaneous melanoma survival"],"prefix":"10.1002","volume":"142","author":[{"given":"Bo","family":"Li","sequence":"first","affiliation":[{"name":"Duke Cancer Institute, Duke University Medical Center Durham NC"},{"name":"Department of Medicine Duke University School of Medicine Durham NC"},{"name":"Department of Obstetrics and Gynecology Shengjing Hospital of China Medical University Shenyang Liaoning People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanru","family":"Wang","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, Duke University Medical Center Durham NC"},{"name":"Department of Medicine Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Xu","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, Duke University Medical Center Durham NC"},{"name":"Department of Medicine Duke University School of Medicine Durham NC"},{"name":"Cancer Center The First Hospital of Jilin University Changchun Jilin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7639-0904","authenticated-orcid":false,"given":"Hongliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, Duke University Medical Center Durham NC"},{"name":"Department of Medicine Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Bloomer","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, Duke University Medical Center Durham NC"},{"name":"Department of Medicine Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dakai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Community and Family Medicine Geisel School of Medicine, Dartmouth College Hanover NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher I.","family":"Amos","sequence":"additional","affiliation":[{"name":"Community and Family Medicine Geisel School of Medicine, Dartmouth College Hanover NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenying","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Han","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3845-9445","authenticated-orcid":false,"given":"Qingyi","family":"Wei","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, Duke University Medical Center Durham NC"},{"name":"Department of Medicine Duke University School of Medicine Durham NC"},{"name":"Department of Population Health Sciences Duke University School of Medicine Durham 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