{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:55:07Z","timestamp":1792590907373,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA74415"],"award-info":[{"award-number":["R01CA74415"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000015","name":"Canadian Cancer Society Research Institute","doi-asserted-by":"publisher","award":["703058"],"award-info":[{"award-number":["703058"]}],"id":[{"id":"10.13039\/501100000015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Tobacco smoke is an established carcinogen, but the association between tobacco smoking and cancer risk in <jats:italic>BRCA<\/jats:italic> mutation carriers is not clear. The aim of this study was to evaluate prospectively the association between tobacco smoking and cancer incidence in a cohort of <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> mutation carriers. The study population consisted of unaffected <jats:italic>BRCA<\/jats:italic> mutation carriers. Information on lifestyle including smoking histories, reproductive factors, and past medical histories was obtained through questionnaires. Incident cancers were updated biennially via follow\u2010up questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using time\u2010dependent Cox regression models. There were 700 incident cancers diagnosed over 26,711 person\u2010years of follow\u2010up. The most frequent cancers seen in <jats:italic>BRCA<\/jats:italic> mutation carriers were breast (<jats:italic>n<\/jats:italic>\u2009=\u2009428; 61%) and ovarian (<jats:italic>n<\/jats:italic>\u2009=\u2009109; 15%) cancer. Compared to nonsmokers, (ever) smoking was associated with a modest increased risk of all cancers combined (HR\u2009=\u20091.17; 95%CI 1.01\u20131.37). Women in the highest group of total pack\u2010years (4.3\u20139.8) had an increased risk of developing any cancer (HR\u2009=\u20091.27; 95%CI 1.04\u20131.56), breast cancer (HR\u2009=\u20091.33, 95%CI 1.02\u20131.75), and ovarian cancer (HR\u2009=\u20091.68; 95%CI 1.06\u20132.67) compared to never smokers. The associations between tobacco smoking and cancer did not differ by <jats:italic>BRCA<\/jats:italic> mutation type or by age at diagnosis. This prospective study suggests that tobacco smoking is associated with a modest increase in the risks of breast and ovarian cancer among women with <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> mutation.<\/jats:p>","DOI":"10.1002\/ijc.31257","type":"journal-article","created":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T13:47:03Z","timestamp":1515851223000},"page":"2263-2272","source":"Crossref","is-referenced-by-count":30,"title":["The association between smoking and cancer incidence in <i>BRCA1<\/i> and <i>BRCA2<\/i> mutation carriers"],"prefix":"10.1002","volume":"142","author":[{"given":"Kwang\u2010Pil","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine Gachon University College of Medicine Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shana J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Women's College Research Institute, Women's College Hospital Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Huzarski","sequence":"additional","affiliation":[{"name":"International Hereditary Cancer Center, Department of Genetics and Pathology Pomeranian Medical University Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Gronwald","sequence":"additional","affiliation":[{"name":"International Hereditary Cancer Center, Department of Genetics and Pathology Pomeranian Medical University Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lubinski","sequence":"additional","affiliation":[{"name":"International Hereditary Cancer Center, Department of Genetics and Pathology Pomeranian Medical University Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry T.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health Creighton University School of Medicine Omaha NE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Armel","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology University of Toronto  ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue K","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Karlan","sequence":"additional","affiliation":[{"name":"Gynecology Oncology, Cedars Sinai Medical Center Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian F.","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Comprehensive Cancer Center Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Neuhausen","sequence":"additional","affiliation":[{"name":"Department of Population Sciences Beckman Research Institute of City of Hope Duarte CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-0626","authenticated-orcid":false,"given":"Steven A.","family":"Narod","sequence":"additional","affiliation":[{"name":"Women's College Research Institute, Women's College Hospital Toronto ON Canada"},{"name":"Dalla Lana School of Public Health University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Kotsopoulos","sequence":"additional","affiliation":[{"name":"Women's College Research Institute, Women's College Hospital Toronto ON Canada"},{"name":"Dalla Lana School of Public Health University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Hereditary Breast Cancer Clinical Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,25]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"International Agency for Research Center. 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