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Registry linkages in Hawaii and California identified 5,284 incident CRC cases. After exclusion of cases with pre\u2010existing cancer diagnosis within 1 year and systemic disease, the analytic dataset had 3,913 cases with 1,800 all\u2010cause and 678 CRC\u2010specific deaths after a mean follow\u2010up of 9.3\u2009\u00b1\u20095.2 years. Among CRC cases, 707 were diagnosed with T2D 8.9\u2009\u00b1\u20095.3 years before CRC. Cox regression with age as time metric was applied to estimate hazard ratios (HR) and 95% confidence intervals (CI) for T2D status as predictor of CRC\u2010specific and all\u2010cause survival while adjusting for known confounders. Overall, CRC\u2010specific survival was not associated with pre\u2010existing T2D (HR\u2009=\u20090.84; 95% CI\u2009=\u20090.67\u20131.07). However, a significant interaction was seen for comorbidity (<jats:italic>p<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0=\u00a00.03) with better survival among those without pre\u2010existing conditions (HR\u2009=\u20090.49; 95% CI\u2009=\u20090.25\u20130.96) while no association was seen in patients with comorbid conditions. All\u2010cause mortality was also not related to pre\u2010existing T2D (HR\u2009=\u20091.11; 95% CI\u2009=\u20090.98\u20131.27), but significantly elevated for individuals with T2D reporting comorbid conditions (HR\u2009=\u20091.36; 95% CI\u2009=\u20091.19\u20131.56). Stratification by T2D duration suggested higher CRC\u2010specific and all\u2010cause mortality among participants with a T2D history of \u226510 than &lt;10 years. The findings were consistent across sex and ethnic subgroups. In contrast to previous reports, pre\u2010existing T2D had no influence on disease\u2010specific and all\u2010cause survival among CRC patients. Only participants with additional comorbidity and possibly those with long T2D duration experienced higher mortality related to T2D.<\/jats:p>","DOI":"10.1002\/ijc.31311","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T08:23:05Z","timestamp":1518596585000},"page":"263-268","source":"Crossref","is-referenced-by-count":27,"title":["Type 2 diabetes and colorectal cancer survival: The multiethnic cohort"],"prefix":"10.1002","volume":"143","author":[{"given":"Yvette","family":"Amshoff","sequence":"first","affiliation":[{"name":"Epidemiology Program, University of Hawaii Cancer Center Honolulu HI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8129-958X","authenticated-orcid":false,"given":"Gertraud","family":"Maskarinec","sequence":"additional","affiliation":[{"name":"Epidemiology Program, University of Hawaii Cancer Center Honolulu HI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurii B.","family":"Shvetsov","sequence":"additional","affiliation":[{"name":"Epidemiology Program, University of Hawaii Cancer Center Honolulu HI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis H.","family":"Raquinio","sequence":"additional","affiliation":[{"name":"Epidemiology Program, University of Hawaii Cancer Center Honolulu HI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Grandinetti","sequence":"additional","affiliation":[{"name":"Office of Public Health Studies University of Hawaii Honolulu HI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica W.","family":"Setiawan","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine, and Norris Comprehensive Cancer Center University of Southern California Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Haiman","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine, and Norris Comprehensive Cancer Center University of Southern California Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Le Marchand","sequence":"additional","affiliation":[{"name":"Epidemiology Program, University of Hawaii Cancer Center Honolulu HI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22532"},{"key":"e_1_2_5_3_1","unstructured":"HowladerN NooneA KrapchoM.SEER cancer statistics review 1975\u20132013.http:\/\/seer.cancer.gov\/csr\/1975_2013\/.2016. 6\u201320\u20102016."},{"key":"e_1_2_5_4_1","unstructured":"International Diabetes Federation. 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