{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:42:24Z","timestamp":1784641344971,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T00:00:00Z","timestamp":1519948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,7,15]]},"abstract":"<jats:p>Human papillomavirus (HPV)\u2010induced oropharyngeal squamous cell carcinoma (OPSCC) remains increasing worldwide. We aimed to investigate if the HPV\u2010prevalence of OPSCC in the Netherlands is rising as well, also in female patients. In addition, we evaluated the association between HPV\u2010positive OPSCC and suspicious Pap results of the cervix in these female patients. Patients with OPSCC treated in the period 2000\u20132015 at the VU University Medical Center Amsterdam, were included (<jats:italic>n<\/jats:italic>\u2009=\u2009926). The presence of an oncogenic HPV infection was determined by p16\u2010immunostaining, followed by a high\u2010risk HPV general primer 5+\/6+ DNA PCR on the p16\u2010immunopositive cases. A review of pathology reports in all female patients (<jats:italic>n<\/jats:italic>\u2009=\u2009305) was undertaken to identify cytological signs of HPV\u2010related (pre)cancer of the cervix. In total 281 of 926 (30.3%) OPSCCs were HPV\u2010positive. Moreover, a significant increase in the prevalence of HPV\u2010positive OPSCCs was observed from 14.0% in 2000 to 48.1% in 2015 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Among the female patients with an HPV\u2010positive OPSSC (<jats:italic>n<\/jats:italic>\u2009=\u200970), the results of cervical smears were available in 56 of 70 patients (80.0%). Of the female patients with HPV\u2010positive OPSCC, 9 of 56 (16.1%) patients had a vaginal cuff Papanicolaou (Pap) test \u22653b in their medical history compared to 7 of 168 (4.2%) in the HPV\u2010negative group (<jats:italic>p<\/jats:italic>\u2009=\u20090.003). In conclusion, a continuous increase in the HPV\u2010attributable fraction of OPSCC was demonstrated in the period 2000\u20132015 in the Amsterdam region. HPV\u2010positive OPSCC has a significant association with a history of suspicious Pap results of the cervix in female patients.<\/jats:p>","DOI":"10.1002\/ijc.31315","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T08:12:49Z","timestamp":1518595969000},"page":"283-288","source":"Crossref","is-referenced-by-count":30,"title":["Epidemiologic associations of HPV\u2010positive oropharyngeal cancer and (pre)cancerous cervical lesions"],"prefix":"10.1002","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2567-2703","authenticated-orcid":false,"given":"M.M.","family":"Rietbergen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery VU University Medical Center, Cancer Center Amsterdam  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.J.D.","family":"van Bokhoven","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck 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