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We evaluated stand\u2010alone genotyping as a possible triage method. During a multicentre randomised controlled trial comparing HPV testing to conventional cytology, HPV\u2010positive women were referred to colposcopy and followed up if no high\u2010grade lesion was detected. HPV\u2010positive samples were genotyped by GP5+\/GP6+ primed polymerase chain reaction followed by reverse line blot. Genotypes were hierarchically ordered by positive predictive value (PPV) for CIN grade 2 or more (CIN2+), and grouped by cluster analysis into three groups (A, B and C in decreasing order). Receiver operating characteristic curves were computed. Among 2,255 HPV\u2010positive women with genotyping, 239 CIN2+ (including 113 CIN3+) were detected at baseline or during a 3\u2010year follow\u2010up. HPV33 had the highest PPV with CIN2+ and CIN3+ as the endpoint and when considering lesions detected at baseline or also during follow\u2010up. HPV16 and HPV35 were the second and third, respectively. Cross\u2010sectional sensitivity for CIN2+ at baseline was 67.3% (95% CI 59.7\u201374.2), 91.8% (95% CI 86.6\u201395.5) and 94.7% (95% CI 90.2\u201397.6), respectively, when considering as \u201cpositive\u201d any of the HPV types in group A (33, 16 and 35), A or B (31, 52, 18, 59 and 58) and A or B or C (39, 51, 56, 45 and 68). The corresponding cross\u2010sectional PPVs for CIN2+ were 15.8% 95% (CI 13.2\u201318.7), 12.0% (95% CI 10.3\u201313.9) and 9.6% (95% CI 8.2\u201311.1), respectively. HPV33, 16 and 35 confer a high probability of CIN2+ but this rapidly decreases when adding other genotypes.<\/jats:p>","DOI":"10.1002\/ijc.31326","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T08:38:43Z","timestamp":1518856723000},"page":"333-342","source":"Crossref","is-referenced-by-count":23,"title":["Human papilloma virus genotyping for the cross\u2010sectional and longitudinal probability of developing cervical intraepithelial neoplasia grade 2 or more"],"prefix":"10.1002","volume":"143","author":[{"given":"Annarosa","family":"Del Mistro","sequence":"first","affiliation":[{"name":"Veneto Institute of Oncology IOV\u2014IRCCS Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Adcock","sequence":"additional","affiliation":[{"name":"Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Carozzi","sequence":"additional","affiliation":[{"name":"Institute for Cancer Study and Prevention (ISPO) Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gillio\u2010Tos","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology\u2014CERMS, University of Turin  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"De Marco","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology\u2014CERMS, University of Turin  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Girlando","sequence":"additional","affiliation":[{"name":"Pathology Unit, S. 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