{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:14:47Z","timestamp":1791515687923,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000321","name":"World Cancer Research Fund","doi-asserted-by":"publisher","award":["2013\/995"],"award-info":[{"award-number":["2013\/995"]}],"id":[{"id":"10.13039\/501100000321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>Current convincing evidence suggests that alcohol intake increases the risk of several carcinomas, which might subsequently lead to a recommendation toward limiting alcohol consumption. However, there are accumulating data worth meta\u2010analyzing that show a different effect on the risk of hematological malignancies. Eligible cohort studies were sought in PubMed database up to August 31, 2016. Separate analyses were performed by subtype of hematological malignancy (non\u2010Hodgkin lymphoma [NHL] and subtypes, Hodgkin lymphoma [HL], leukemia and subtypes), time status (ever, current, former), level of consumption (light, moderate, heavy), alcoholic beverage (total alcohol, beer, liquor, wine) and gender. Moderate and heavy alcohol consumption were significantly associated with reduced risk of NHL (relative risk [RR]\u2009=\u20090.85, 95% confidence interval [CI]: 0.80\u20130.90 and RR\u2009=\u20090.73, 95%CI: 0.60\u20130.89, respectively); a protective trend was also shown for light alcohol intake (RR\u2009=\u20090.93, 95%CI: 0.87\u20131.00). Specifically, beer consumption was associated with reduced NHL risk (RR\u2009=\u20090.88, 95%CI: 0.81\u20130.95). However, the association regarding other alcoholic beverages seemed null. The beneficial effects of alcohol mainly pertained to Diffuse Large B\u2010Cell Lymphoma (DLBCL) (RR\u2009=\u20090.83, 95%CI: 0.77\u20130.89) and Follicular Lymphoma (FL) (RR\u2009=\u20090.85, 95%CI: 0.78\u20130.93). There was also no association between alcohol consumption and risk of HL or leukemias. In contrast to most solid malignancies, alcohol seems to confer a protective effect on NHL risk, especially on DLBCL and FL subtypes, with beer being notably beneficial.<\/jats:p>","DOI":"10.1002\/ijc.31330","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T18:45:12Z","timestamp":1519238712000},"page":"486-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Alcohol consumption and risk of hematological malignancies: A meta\u2010analysis of prospective studies"],"prefix":"10.1002","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1404-9716","authenticated-orcid":false,"given":"Theodora","family":"Psaltopoulou","sequence":"first","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics School of Medicine, National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros N.","family":"Sergentanis","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics School of Medicine, National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Ntanasis\u2010Stathopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine, National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis\u2010Georgios","family":"Tzanninis","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics School of Medicine, National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diamantis I.","family":"Tsilimigras","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics School of Medicine, National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meletios A.","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine, National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Global Status Report on Alcohol and Health World Health Organization: Geneva, Switzerland","author":"World Health Organization","year":"2014"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2012.301199"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d1584"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds022"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2016.161"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.579"},{"key":"e_1_2_5_8_1","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow SHCE","year":"2008"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.1993.1034"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0093"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-004-7115-1"},{"key":"e_1_2_5_12_1","first-page":"515","article-title":"Risk factors and primary prevention of acute leukemia","volume":"7","author":"Ilhan G","year":"2006","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2013.07.014"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2014.048"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e328355ed08"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.06.029"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25768"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25387"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-1081"},{"key":"e_1_2_5_20_1","unstructured":"World Cancer Research Fund\/American Institute for Cancer Research. Continuous update project report. Food nutrition physical activity and the prevention of colorectal cancer. London: WCRF\/AICR 2011."},{"key":"e_1_2_5_21_1","unstructured":"World Cancer Research Fund\/American Institute for Cancer Research. Food nutrition physical activity and the prevention of endometrial cancer. London: WCRF 2013."},{"key":"e_1_2_5_22_1","unstructured":"World Cancer Research Fund\/American Institute for Cancer Research. Continuous update project report. Food nutrition physical activity and the prevention of ovarian cancer. London: WCRF 2014."},{"key":"e_1_2_5_23_1","unstructured":"HigginsJ GreenS.Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011] 2011. The Cochrane Collaboration. Available from:http:\/\/handbook.cochrane.org\/."},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2014.06.001"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds013"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e328350b11b"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199305000-00005"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4041"},{"key":"e_1_2_5_29_1","unstructured":"WellsG SheaB O'connellD et al. The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta\u2010analyses. Dept of Epidemiology and Community Medicine University of Ottawa: Ottawa Canada 2011. Available from:http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.htm. Accessed on January 30 2017."},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-015-0089-3"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm122"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2009.03.005"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2014.03.003"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.956312"},{"key":"e_1_2_5_35_1","unstructured":"World Cancer Research Fund. Alcohol & cancer 2014. Available at:https:\/\/www.wcrf.org\/int\/cancer-facts-figures\/link-between-lifestyle-cancer-risk\/alcohol-cancer(accessed on Aug 01 2017)"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-11-191783"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-015-0091-0"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.266"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-9-14"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-362830"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200011000-00004"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj330"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.623"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181f44abc"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq309"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690547"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-1088"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2009.02696.x"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.31330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.31330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T21:06:39Z","timestamp":1695416799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.31330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,30]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/ijc.31330"],"URL":"https:\/\/doi.org\/10.1002\/ijc.31330","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,30]]},"assertion":[{"value":"2017-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}