{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:57:13Z","timestamp":1791644233251,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703394"],"award-info":[{"award-number":["81703394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>High\u2010risk (hr) human papillomavirus (HPV) infection is closely associated with the clinical conditions of both squamous intraepithelial lesions (SILs) and cervical carcinoma. However, it remains unclear what factors determine the type of hrHPV infection. Here, we have comprehensively investigated the bacterial composition of the cervicovaginal microbiota of 280 women infected with one type of hrHPV (HPV 16, 52 or 58) by the pyrosequencing of barcoded 16S rRNA genes. Differential microbiota composition was observed among various SIL groups and within the subgroups of each group. This result showed that it is not the microbiota diversity or the common microbiota, but rather agents that are specific to each SIL that might have a positive influence on the acquisition of hrHPV types, independent of abundance. Specifically, a composition of <jats:italic>Oribacterium<\/jats:italic>, <jats:italic>Lachnobacterium<\/jats:italic> and <jats:italic>Thermus<\/jats:italic> in the cervicovaginal microbiota is more likely to be associated with HPV 16, while a composition of <jats:italic>Motilibacter<\/jats:italic> in the cervicovaginal microbiota is more likely to be associated with HPV 52, and a composition of <jats:italic>Litorilinea<\/jats:italic> and <jats:italic>Paludibaculum<\/jats:italic> with a concomitant paucity of <jats:italic>L. iners<\/jats:italic> in the cervicovaginal microbiota is more likely to be associated with HPV 58. Furthermore, functional predictions regarding infectious diseases and cancer\u2010related genes disclosed significant differences (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) among the different (sub)groups. Our study provides an elucidation of the relationship between the composition of the cervicovaginal microbiota and the type of hrHPV acquired.<\/jats:p>","DOI":"10.1002\/ijc.31342","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T06:22:40Z","timestamp":1519626160000},"page":"621-634","source":"Crossref","is-referenced-by-count":62,"title":["Cervicovaginal microbiota composition correlates with the acquisition of high\u2010risk human papillomavirus types"],"prefix":"10.1002","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9184-8784","authenticated-orcid":false,"given":"Xiaojie","family":"Huang","sequence":"first","affiliation":[{"name":"Clinical and Translational Research Center Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine Shanghai People's Republic of 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