{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:21:30Z","timestamp":1784953290669,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007913","name":"Breast Cancer Now","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007913","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,8,15]]},"abstract":"<jats:p>Preeclampsia and hyperemesis gravidarum are pregnancy complications associated with altered sex hormone levels. Previous studies suggest preeclampsia may be associated with a decreased risk of subsequent breast cancer and hyperemesis with an increased risk, but the evidence remains unclear. We used data from the Generations Study, a large prospective study of women in the United Kingdom, to estimate relative risks of breast cancer in relation to a history of preeclampsia and hyperemesis using Cox regression adjusting for known breast cancer risk factors. During 7.5 years average follow\u2010up of 82,053 parous women, 1,969 were diagnosed with invasive or<jats:italic>in situ<\/jats:italic>breast cancer. Women who had experienced preeclampsia during pregnancy had a significantly decreased risk of premenopausal breast cancer (hazard ratio (HR) =0.67, 95% confidence interval (CI): 0.49\u20130.90) and of HER2\u2010enriched tumours (HR\u2009=\u20090.33, 95% CI: 0.12\u20130.91), but there was no association with overall (HR\u2009=\u20090.90, 95% CI: 0.80\u20131.02) or postmenopausal (HR\u2009=\u20090.97, 95% CI: 0.85\u20131.12) breast cancer risk. Risk reductions among premenopausal women were strongest within 20 years since the last pregnancy with preeclampsia. Hyperemesis was associated with a significantly increased risk of HER2\u2010enriched tumours (HR\u2009=\u20091.76, 95% CI: 1.07\u20132.87), but not with other intrinsic subtypes or breast cancer risk overall. These results provide evidence that preeclampsia is associated with a decreased risk of premenopausal and HER2\u2010enriched breast cancer and that hyperemesis, although not associated with breast cancer risk overall, may be associated with raised risk of HER2\u2010enriched tumours.<\/jats:p>","DOI":"10.1002\/ijc.31364","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T07:53:14Z","timestamp":1520495594000},"page":"782-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study"],"prefix":"10.1002","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4119-0037","authenticated-orcid":false,"given":"Lauren B.","family":"Wright","sequence":"first","affiliation":[{"name":"Division of Genetics and Epidemiology The Institute of Cancer Research London 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