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Further, DNA copy number alterations (CNAs), which can result from radiation\u2010induced double\u2010strand breaks, are frequently occurring in breast cancer cells. We set out to identify a signature of CNAs discriminating breast cancers from radiation\u2010exposed and non\u2010exposed female patients. We analyzed resected breast cancer tissues from 68 exposed female Chernobyl clean\u2010up workers and evacuees and 68 matched non\u2010exposed control patients for CNAs by array comparative genomic hybridization analysis (aCGH). Using a stepwise forward\u2013backward selection approach a non\u2010complex CNA signature, that is, less than ten features, was identified in the training data set, which could be subsequently validated in the validation data set (<jats:italic>p<\/jats:italic> value\u2009&lt;\u20090.05). The signature consisted of nine copy number regions located on chromosomal bands 7q11.22\u201011.23, 7q21.3, 16q24.3, 17q21.31, 20p11.23\u201011.21, 1p21.1, 2q35, 2q35, 6p22.2. The signature was independent of any clinical characteristics of the patients. In all, we identified a CNA signature that has the potential to allow identification of radiation\u2010associated breast cancer at the individual level.<\/jats:p>","DOI":"10.1002\/ijc.31533","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T04:34:04Z","timestamp":1523939644000},"page":"1505-1515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A genomic copy number signature predicts radiation exposure in post\u2010<scp>C<\/scp>hernobyl breast cancer"],"prefix":"10.1002","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-4033","authenticated-orcid":false,"given":"Christina M.","family":"Wilke","sequence":"first","affiliation":[{"name":"Research Unit Radiation Cytogenetics, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH Neuherberg 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