{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:23:43Z","timestamp":1768908223274,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","award":["AIRC IG No. 19112"],"award-info":[{"award-number":["AIRC IG No. 19112"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>This cohort study assessed, in Italy, the overall pattern of risk of <jats:italic>de novo<\/jats:italic> malignancies following liver transplantation (LT). The study group included 2,832 individuals who underwent LT between 1985 and 2014 in nine centers all over Italy. Person\u2013years (PYs) at cancer risk were computed from 30 days after LT to the date of cancer diagnosis, to the date of death or to the end of follow\u2010up. Excess cancer risk, as compared to the general population, was estimated using standardized incidence ratios (SIRs) and 95% confidence intervals (CIs). During 18,642 PYs, 246 LT recipients developed 266 <jats:italic>de novo<\/jats:italic> malignancies, corresponding to a 1.8\u2010fold higher cancer risk (95% CI: 1.6\u20132.0). SIRs were particularly elevated for virus\u2010related malignancies, including Kaposi's sarcoma (SIR\u2009=\u200953.6, 95% CI: 30.0\u201388.5), non\u2010Hodgkin lymphomas (SIR\u2009=\u20097.1, 95% CI: 4.8\u201310.1) and cervix uteri (SIR\u2009=\u20095.4, 95% CI: 1.1\u201315.8). Among virus\u2010unrelated malignancies, elevated risks emerged for head and neck (SIR\u2009=\u20094.4, 95% CI: 3.1\u20136.2), esophagus (SIR\u2009=\u20096.7, 95% CI: 2.9\u201313.3) and adrenal gland (SIR\u2009=\u200922.9, 95% CI: 2.8\u201382.7). Borderline statistically significant elevated risks were found for lung cancer (SIR\u2009=\u20091.4, 95% CI: 1.0\u20132.1) and skin melanoma (SIR\u2009=\u20092.6, 95% CI: 1.0\u20135.3). A reduced risk emerged for prostate cancer (SIR\u2009=\u20090.1, 95% CI: 0.0\u20130.5). These findings underline the need of preventive interventions and early detection of malignancies, specifically tailored to LT recipients.<\/jats:p>","DOI":"10.1002\/ijc.31552","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T10:22:17Z","timestamp":1524651737000},"page":"1588-1594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Risk of virus and non\u2010virus related malignancies following immunosuppression in a cohort of liver transplant recipients. Italy, 1985\u20132014"],"prefix":"10.1002","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-7569","authenticated-orcid":false,"given":"Martina","family":"Taborelli","sequence":"first","affiliation":[{"name":"Unit of Cancer Epidemiology CRO Aviano National Cancer Institute Aviano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluca","family":"Piselli","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Pre\u2010Clinical Research National Institute for Infectious Diseases \u201cL. Spallanzani\u201d Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe Maria","family":"Ettorre","sequence":"additional","affiliation":[{"name":"Division of General Surgery and Liver Transplantation S. Camillo Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"Lauro","sequence":"additional","affiliation":[{"name":"Liver and Multiorgan Transplant Unit S. Orsola\u2010Malpighi University Hospital Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Galatioto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), University of Pittsburgh Medical Center Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Baccarani","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Udine Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Rendina","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Section of Gastroenterology University Hospital Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Shalaby","sequence":"additional","affiliation":[{"name":"Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology Padua University Hospital Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Petrara","sequence":"additional","affiliation":[{"name":"Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology Padua University Hospital Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Nudo","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Organ Transplantation Umberto I Policlinic, Sapienza University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Toti","sequence":"additional","affiliation":[{"name":"UOC Transplant Unit, Department of Surgery Tor Vergata University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Sforza","sequence":"additional","affiliation":[{"name":"UOC Transplant Unit, Department of Surgery Tor Vergata University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Fantola","sequence":"additional","affiliation":[{"name":"Department of Surgery General and Hepatic Transplantation Surgery Unit, A.O.B. 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Camillo Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Daniele","family":"Pinna","sequence":"additional","affiliation":[{"name":"Liver and Multiorgan Transplant Unit S. 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