{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:47:56Z","timestamp":1791157676073,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T00:00:00Z","timestamp":1526169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31330036"],"award-info":[{"award-number":["31330036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31500960"],"award-info":[{"award-number":["31500960"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31530034"],"award-info":[{"award-number":["31530034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31570791"],"award-info":[{"award-number":["31570791"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["71490732"],"award-info":[{"award-number":["71490732"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91542205"],"award-info":[{"award-number":["91542205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["LZ15H160002"],"award-info":[{"award-number":["LZ15H160002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Numerous studies have suggested that excess body weight is associated with increased cancer risk. To examine this putative association, we performed a systematic review and quantitative meta\u2010analysis of cohort studies reporting body mass index (BMI) and the risk of 23 cancer types. PubMed, Embase, and Web of Science were searched for cohort studies, yielding 325 articles with 1,525,052 cases. Strong positive associations were observed between BMI and endometrial cancer (RR: 1.48), esophageal adenocarcinoma (RR: 1.45), and kidney cancer (RR: 1.20); weaker associations (RR\u00a0&lt;\u00a01.20) were also found for several other cancer types. Interestingly, we found significant inverse associations between BMI and oral cavity (RR: 0.93), lung (RR: 0.91), premenopausal breast (RR: 0.95), and localized prostate (RR: 0.97) cancers. A male\u2010specific association was found for colorectal cancer (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.023), and a female\u2010specific association was found for cancer in brain (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.025) or kidney (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.035). With respect to geography, the strongest positive association was found for total cancer in North America (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.038). This comprehensive meta\u2010analysis provides epidemiological evidence supporting the association between BMI and cancer risk. These findings can be used to drive public policies and to help guide personalized medicine in order to better manage body weight, thereby reducing the risk of developing obesity\u2010related cancer.<\/jats:p>","DOI":"10.1002\/ijc.31553","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T08:28:09Z","timestamp":1524731289000},"page":"1595-1603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["<scp>Q<\/scp>uantitative association between body mass index and the risk of cancer: <scp>A<\/scp> global Meta\u2010analysis of prospective cohort studies"],"prefix":"10.1002","volume":"143","author":[{"given":"Xuexian","family":"Fang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital, Institute of Translational Medicine, Institute of Nutrition and Food Safety, School of Public Health, School of Medicine, Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Wei","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Institute of Translational Medicine, Institute of Nutrition and Food Safety, School of Public Health, School of Medicine, Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyan","family":"He","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Institute of Translational Medicine, Institute of Nutrition and Food Safety, School of Public Health, School of Medicine, Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Lian","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Institute of Translational Medicine, Institute of Nutrition and Food Safety, School of Public Health, School of Medicine, Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Han","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Institute of Translational Medicine, Institute of Nutrition and Food Safety, School of Public Health, School of Medicine, Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"An","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Institute of Translational Medicine, Institute of Nutrition and Food Safety, School of Public Health, School of Medicine, Zhejiang University Hangzhou China"},{"name":"Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Program in Molecular Cell Biology School of Medicine, Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Liu","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Medicine Brown University Providence Rhode Island United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-0003","authenticated-orcid":false,"given":"Fudi","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Institute of Translational Medicine, Institute of Nutrition and Food Safety, School of Public Health, School of Medicine, Zhejiang University Hangzhou China"},{"name":"Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxia","family":"Min","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Institute of Translational Medicine, Institute of Nutrition and Food Safety, School of Public Health, School of Medicine, Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60460-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.199"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-7954-10-22"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010112"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60105-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12129"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.576967"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(02)00849-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1408"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.94"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60892-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60269-X"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4490"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e8539"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116237"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0600600103"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk006"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.005363"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6879"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/80.15.1198"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1187"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds508"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5453"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.010"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.5301\/JBM.5000047"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv142"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2015.04.017"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000075"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0832"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66455-0"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605496"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i2156"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002966510800712X"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327481302000207"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0265"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.041517"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0042"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep07480"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0070"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801406"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0633"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30819-X"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801891"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803193"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801013380101"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2006.00248.x"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-006-9074-1"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/291546"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63930"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2013.02.010"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-121211-091527"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.31553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.31553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.31553","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.31553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T12:49:32Z","timestamp":1694177372000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.31553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,13]]},"references-count":58,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/ijc.31553"],"URL":"https:\/\/doi.org\/10.1002\/ijc.31553","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,13]]},"assertion":[{"value":"2017-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}