{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:11:13Z","timestamp":1791994273164,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T00:00:00Z","timestamp":1530576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005972","name":"German Cancer Aid","doi-asserted-by":"publisher","award":["111010"],"award-info":[{"award-number":["111010"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Danish Council for Independent Research","doi-asserted-by":"publisher","award":["DFF\u20104004\u201300179"],"award-info":[{"award-number":["DFF\u20104004\u201300179"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000321","name":"World Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Danish Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Air pollution has been classified as carcinogenic to humans. However, to date little is known about the relevance for cancers of the stomach and upper aerodigestive tract (UADT). We investigated the association of long\u2010term exposure to ambient air pollution with incidence of gastric and UADT cancer in 11 European cohorts. Air pollution exposure was assigned by land\u2010use regression models for particulate matter (PM) below 10 \u00b5m (PM<jats:sub>10<\/jats:sub>), below 2.5 \u00b5m (PM<jats:sub>2.5<\/jats:sub>), between 2.5 and 10 \u00b5m (PM<jats:sub>coarse<\/jats:sub>), PM<jats:sub>2.5<\/jats:sub> absorbance and nitrogen oxides (NO<jats:sub>2<\/jats:sub> and NO<jats:sub>X<\/jats:sub>) as well as approximated by traffic indicators. Cox regression models with adjustment for potential confounders were used for cohort\u2010specific analyses. Combined estimates were determined with random effects meta\u2010analyses. During average follow\u2010up of 14.1 years of 305,551 individuals, 744 incident cases of gastric cancer and 933 of UADT cancer occurred. The hazard ratio for an increase of 5 \u00b5g\/m<jats:sup>3<\/jats:sup> of PM<jats:sub>2.5<\/jats:sub> was 1.38 (95% CI 0.99; 1.92) for gastric and 1.05 (95% CI 0.62; 1.77) for UADT cancers. No associations were found for any of the other exposures considered. Adjustment for additional confounders and restriction to study participants with stable addresses did not influence markedly the effect estimate for PM<jats:sub>2.5<\/jats:sub> and gastric cancer. Higher estimated risks of gastric cancer associated with PM<jats:sub>2.5<\/jats:sub> was found in men (HR 1.98 [1.30; 3.01]) as compared to women (HR 0.85 [0.5; 1.45]). This large multicentre cohort study shows an association between long\u2010term exposure to PM<jats:sub>2.5<\/jats:sub> and gastric cancer, but not UADT cancers, suggesting that air pollution may contribute to gastric cancer risk.<\/jats:p>","DOI":"10.1002\/ijc.31564","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T08:31:30Z","timestamp":1524731490000},"page":"1632-1643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE)"],"prefix":"10.1002","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6185-8535","authenticated-orcid":false,"given":"Gabriele","family":"Nagel","sequence":"first","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry, Ulm University Ulm Germany"},{"name":"Agency for 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