{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:46:29Z","timestamp":1790786789319,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Epidemiological studies have suggested that prostatitis may increase the risk of prostate cancer due to chronic inflammation. We studied the association between several genitourinary infections and the risk of prostate cancer based on data from the EPICAP study. EPICAP is a population\u2010based case\u2010control study conducted in the <jats:italic>d\u00e9partement<\/jats:italic> of H\u00e9rault, France, between 2012 and 2014. A total of 819 incident cases and 879 controls have been face to face interviewed using a standardized questionnaire gathering information on known or suspected risk factors of prostate cancer, and personal history of genitourinary infections: prostatitis, urethritis, orchi\u2010epididymitis, and acute pyelonephritis. Odds Ratios (OR) and their 95% confidence interval were estimated using multivariate unconditional logistic regression. Overall, 139 (18%) cases and 98 (12%) controls reported having at least one personal history of genitourinary infections (OR\u00a0=\u00a01.64 [1.23\u20132.20]). The risk increased with the number of infections (<jats:italic>p<\/jats:italic>\u2010trend\u00a0&lt;\u00a00.05). The association was specifically observed with personal history of chronic prostatitis and acute pyelonephritis (OR\u00a0=\u00a02.95 [1.26\u20136.92] and OR\u00a0=\u00a02.66 [1.29\u20135.51], respectively) and in men who did not use any non\u2010steroidal anti\u2010inflammatory drugs (OR\u00a0=\u00a02.00 [1.37\u20132.91]). Our results reinforce the hypothesis that chronic inflammation, generated by a personal history of genitourinary infections, may play a role in prostate carcinogenesis.<\/jats:p>","DOI":"10.1002\/ijc.31565","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T08:36:21Z","timestamp":1524731781000},"page":"1644-1651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<scp>P<\/scp>rostatitis, other genitourinary infections and prostate cancer risk: <scp>I<\/scp>nfluence of non\u2010steroidal anti\u2010inflammatory drugs? <scp>R<\/scp>esults from the <scp>EPICAP<\/scp> study"],"prefix":"10.1002","volume":"143","author":[{"given":"Sol\u00e8ne","family":"Doat","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, Universit\u00e9 Paris\u2010Sud, CESP (Center for Research in Epidemiology and Population Health), Inserm, Team Cancer and Environment Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguelle","family":"Marous","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, Universit\u00e9 Paris\u2010Sud, CESP (Center for Research in Epidemiology and Population Health), Inserm, Team Cancer and Environment Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Rebillard","sequence":"additional","affiliation":[{"name":"Service Urologie, Clinique Beau Soleil Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Tr\u00e9tarre","sequence":"additional","affiliation":[{"name":"Registre des Tumeurs de l'H\u00e9rault, EA 2415, ICM Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Jean","family":"Lamy","sequence":"additional","affiliation":[{"name":"Service Urologie, Clinique Beau Soleil Montpellier France"},{"name":"Institut m\u00e9dical d'Analyse G\u00e9nomique \u2013 Imagenome, Labosud Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Soares","sequence":"additional","affiliation":[{"name":"Polyclinique Saint Privat B\u00e9ziers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Delbos","sequence":"additional","affiliation":[{"name":"Cabinet Urologie du Polygone Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolphe","family":"Thuret","sequence":"additional","affiliation":[{"name":"Centre Hospitalo\u2010Universitaire, H\u00f4pital Lapeyronie Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Segui","sequence":"additional","affiliation":[{"name":"Service Urologie, Clinique Beau Soleil Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"C\u00e9n\u00e9e","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, Universit\u00e9 Paris\u2010Sud, CESP (Center for Research in Epidemiology and Population Health), Inserm, Team Cancer and Environment Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3363-6411","authenticated-orcid":false,"given":"Florence","family":"Menegaux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, Universit\u00e9 Paris\u2010Sud, CESP (Center for Research in Epidemiology and Population Health), Inserm, Team Cancer and Environment Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2015.04.011"},{"key":"e_1_2_9_3_1","unstructured":"LeoneN VoirinN RocheL et al. 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