{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:16Z","timestamp":1786977796955,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T00:00:00Z","timestamp":1528675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n                    Existing evidence remains inconclusive as to how the association between inactive ALDH2 and esophageal cancer (EC) depends on alcohol consumption. The study is based on the China Kadoorie Biobank cohort, with 10 years follow\u2010up of 0.5 million adults aged 30\u201379 years. ALDH2 activity was assessed by both self\u2010reported flushing response and Glu504Lys (rs671 G\u2009&gt;\u2009A) polymorphism. Among both male and female participants who consumed alcohol less than weekly (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200969,519; 211 EC cases), low active or inactive ALDH2 was not associated with increased EC risk [HRs (95% CIs): GA\n                    <jats:italic>vs<\/jats:italic>\n                    . GG 0.75 (0.54, 1.04); AA\n                    <jats:italic>vs<\/jats:italic>\n                    . GG 1.01 (0.46, 2.20)]. Among male weekly alcohol consumers, both flushing response [\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200959,380; 501 EC cases; HRs (95% CIs): \u201csoon after drinking\u201d\n                    <jats:italic>vs<\/jats:italic>\n                    . \u201cno\u201d flushing response 1.45 (1.05, 2.01)] and rs671 [\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910,692; 94 EC cases; GA\n                    <jats:italic>vs<\/jats:italic>\n                    . GG 3.31 (1.94, 5.67)] were associated with EC risk. The increased EC risk associated with \u201csoon\u201d response or rs671 GA was apparent in men consuming alcohol \u226530g\/d. Among male daily consumers, the HRs (95% CIs) for EC associated with 15g\/d of alcohol were 1.28 (1.15, 1.44) for \u201csoon\u201d response [\n                    <jats:italic>vs<\/jats:italic>\n                    . other responses: 1.12 (1.09, 1.15);\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>interaction<\/jats:sub>\n                    \u2009=\u20090.047;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200936,401, 425 EC cases] and 1.41 (1.08, 1.82) for rs671 GA [\n                    <jats:italic>vs<\/jats:italic>\n                    . GG: 1.16 (1.06, 1.27);\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>interaction<\/jats:sub>\n                    \u2009=\u20090.493;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096,607, 80 EC cases]. Self\u2010reported flushing response had low sensitivity (56.8%) and high specificity (88.4%) in identifying rs671 A allele among male weekly alcohol consumers. In conclusion, low\u2010activity ALDH2 was associated with increased EC risk among male heavy alcohol consumers. More accurate measurement of alcohol\u2010related EC risk allows better achievement of precision prevention.\n                  <\/jats:p>","DOI":"10.1002\/ijc.31566","type":"journal-article","created":{"date-parts":[[2018,4,29]],"date-time":"2018-04-29T22:53:36Z","timestamp":1525042416000},"page":"1652-1661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Association of low\u2010activity ALDH2 and alcohol consumption with risk of esophageal cancer in Chinese adults: A population\u2010based cohort study"],"prefix":"10.1002","volume":"143","author":[{"given":"Canqing","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Bian","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit &amp; Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iona Y.","family":"Millwood","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit &amp; Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin G.","family":"Walters","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit &amp; Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit &amp; Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Hainan Center for Disease Control &amp; Prevention Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Maiji Center for Disease Control &amp; Prevention Tianshui Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Lei","sequence":"additional","affiliation":[{"name":"Maiji Center for Disease Control &amp; Prevention Tianshui Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junshi","family":"Chen","sequence":"additional","affiliation":[{"name":"China National Center for Food Safety Risk Assessment Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengming","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit &amp; Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7916-3870","authenticated-orcid":false,"given":"Jun","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University Health Science Center Beijing China"},{"name":"Peking University Institute of Environmental Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University Health Science Center Beijing China"},{"name":"Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the China Kadoorie Biobank Collaborative Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000249"},{"key":"e_1_2_9_4_1","unstructured":"World Cancer Research Fund International\/American Institute for Cancer Research. 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