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However, few biomarker studies have evaluated NHL risk associated with these fats. We conducted a prospective study of 583 incident NHL cases and 583 individually matched controls with archived pre\u2010diagnosis red blood cell (RBC) specimens in the Nurses\u2019 Health Study (NHS) and Health Professionals Follow\u2010Up Study (HPFS). RBC membrane fatty acid levels were measured using gas chromatography. Using multivariable logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL and major NHL subtypes including T cell NHL (T\u2010NHL), B cell NHL (B\u2010NHL) and three individual B\u2010NHLs: chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL), diffuse large B\u2010cell lymphoma (DLBCL) and follicular lymphoma. RBC SFA and MUFA levels were not associated with NHL risk overall. However, RBC very long chain SFA levels (VLCSFA; 20:0, 22:0, 23:0) were inversely associated with B\u2010NHLs other than CLL\/SLL; ORs (95% CIs) per standard deviation (SD) increase in level were 0.81 (0.70, 0.95) for 20:0, 0.82 (0.70, 0.95) for 22:0 and 0.82 (0.70, 0.96) for 23:0 VLCSFA. Also, both VLCSFA and MUFA levels were inversely associated with T\u2010NHL [ORs (95% CIs) per SD: VLCSFA, 0.63 (0.40, 0.99); MUFA, 0.63 (0.40, 0.99)]. The findings of inverse associations for VLCSFAs with B\u2010NHLs other than CLL\/SLL and for VLCSFA and MUFA with T\u2010NHL suggest an influence of fatty acid metabolism on lymphomagenesis.<\/jats:p>","DOI":"10.1002\/ijc.31602","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T08:40:10Z","timestamp":1526287210000},"page":"1914-1922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non\u2010Hodgkin lymphoma"],"prefix":"10.1002","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0904-7855","authenticated-orcid":false,"given":"Yu\u2010Han","family":"Chiu","sequence":"first","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health Boston MA"},{"name":"Department of Epidemiology Harvard T.H. 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