{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:21:57Z","timestamp":1788009717456,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008700","name":"Centre International de Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,11,15]]},"abstract":"<jats:p>Cancers occurring in children in Africa are often underdiagnosed, or at best diagnosed late. As a result, survival is poor, even for cancers considered \u2018curable\u2019. With limited population\u2010level data, understanding the actual burden and survival from childhood cancers in Africa is difficult. In this study, we aimed at providing survival estimates for the most common types of cancers affecting children aged 0\u201314 years, in three population\u2010based Eastern African registries; Harare, Zimbabwe (Kaposi sarcoma, Wilms tumour (WT), non\u2010Hodgkin lymphoma (NHL), retinoblastoma, and acute lymphocytic leukaemia (ALL)), Kampala, Uganda (Burkitt lymphoma, Kaposi sarcoma, WT, and retinoblastoma), and Nairobi, Kenya (ALL, retinoblastoma, WT, Burkitt lymphoma, and Hodgkin lymphoma). We included cases diagnosed within the years 1998\u20132009 and followed up till the end of 2011. We estimated the observed and relative survival at 1, 3, and 5 years after diagnosis. We studied 627 individual patient records. Median follow\u2010up ranged from 2.2 months for children with Kaposi sarcoma in Harare to 30.2 months for children with ALL in Nairobi. The proportion of children lost to follow\u2010up was highest in the first year after diagnosis. In Harare and Kampala, the 5\u2010year relative survival was &lt;46% for all cancer types. The 5\u2010year relative survival was best for children in Nairobi, though with wider confidence intervals. Survival from childhood cancers in Africa is still poor, even for cancers with good prognosis and potential for cure. Supporting cancer detection, treatment, and registration activities could help improve survival chances for children with cancers in Africa.<\/jats:p>","DOI":"10.1002\/ijc.31723","type":"journal-article","created":{"date-parts":[[2018,7,7]],"date-time":"2018-07-07T04:38:11Z","timestamp":1530938291000},"page":"2409-2415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Survival from childhood cancers in Eastern Africa: A population\u2010based registry study"],"prefix":"10.1002","volume":"143","author":[{"given":"W. Yvonne","family":"Joko\u2010Fru","sequence":"first","affiliation":[{"name":"The African Cancer Registry Network, INCTR African Registry Programme, Nuffield Department of Population Health University of Oxford  Oxford OX2 7HT United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3229-1784","authenticated-orcid":false,"given":"D. Maxwell","family":"Parkin","sequence":"additional","affiliation":[{"name":"The African Cancer Registry Network, INCTR African Registry Programme, Nuffield Department of Population Health University of Oxford  Oxford OX2 7HT United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Borok","sequence":"additional","affiliation":[{"name":"Zimbabwe National Cancer Registry  P.O. Box A449, Avondale, Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Chokunonga","sequence":"additional","affiliation":[{"name":"Zimbabwe National Cancer Registry  P.O. Box A449, Avondale, Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Korir","sequence":"additional","affiliation":[{"name":"Nairobi Cancer Registry Kenya Medical Research Institute  Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Nambooze","sequence":"additional","affiliation":[{"name":"Kampala cancer Registry, Kampala Cancer Registry, Department of Pathology \u2013 College of Health Sciences Makerere University  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Wabinga","sequence":"additional","affiliation":[{"name":"Kampala cancer Registry, Kampala Cancer Registry, Department of Pathology \u2013 College of Health Sciences Makerere University  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biying","family":"Liu","sequence":"additional","affiliation":[{"name":"The African Cancer Registry Network, INCTR African Registry Programme, Nuffield Department of Population Health University of Oxford  Oxford OX2 7HT United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Stefan","sequence":"additional","affiliation":[{"name":"AORTIC  37A Main Road, Mowbray, Cape Town 7705 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2017.755"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.6376"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.137"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70194-3"},{"key":"e_1_2_7_6_1","volume-title":"Cancer Incidence in Five Continents, Vol. XI (Electronic Version)","author":"Bray F","year":"2017"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20910"},{"key":"e_1_2_7_8_1","unstructured":"BrennerH SwaminathanR.Stastistical methods for cancer survival analysis introduction and background.http:\/\/survcan.iarc.fr\/survival\/chap2.pdf(accessed March 16 2018)."},{"key":"e_1_2_7_9_1","first-page":"101","article-title":"The relative survival rate: a statistical methodology","volume":"6","author":"Ederer F","year":"1961","journal-title":"Natl Cancer Inst Monogr"},{"key":"e_1_2_7_10_1","unstructured":"GHO | By category | Life tables. 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