{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:34:29Z","timestamp":1789878869655,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>The role of alcoholic beverages in the etiology of gastric cancer is unclear. Recent summaries showed a positive association between higher alcohol intake and gastric cancer risk, but the magnitude of association is small, there is moderate heterogeneity among studies, and most cases were from Asian populations. We prospectively investigated the associations of alcohol consumption with gastric cardia adenocarcinoma (GCA) and gastric noncardia adenocarcinoma (GNCA) in 490,605 adults, aged 50\u201371 years at baseline who participated in the NIH\u2010AARP diet and health study. Alcohol consumption in the past year was assessed at baseline by questionnaire and defined as total grams of ethanol intake per day or as a categorical variable: nondrinker, up to or including one drink per day, one to three drinks per day and greater than three drinks per day. We used multivariable\u2010adjusted Cox proportional hazards regression to calculate the hazard ratios (HR) and 95% confidence intervals (CI) for associations between alcohol intake and risk of gastric adenocarcinomas. Through 2011, 662 incident cases of GCA and 713 of GNCA occurred. We found no association between higher alcohol consumption and GCA or GNCA, when examined as total alcoholic beverage intake or individual beverage types of beer, wine and liquor. Furthermore, we observed no association by stratum of sex, ethnic group, educational level or smoking status. We did, however, observe lower risk of GNCA among participants who drank up to one drink per day (HR = 0.81, 95% CI: 0.67\u20130.97) compared to nondrinkers. In conclusion, alcohol consumption was not associated with increased risk of GCA or GNCA in this large U.S. cohort.<\/jats:p>","DOI":"10.1002\/ijc.31740","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T08:49:55Z","timestamp":1531298995000},"page":"2749-2757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Alcohol consumption and risk of gastric cardia adenocarcinoma and gastric noncardia adenocarcinoma: A 16\u2010year prospective analysis from the NIH\u2010AARP diet and health cohort"],"prefix":"10.1002","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0420-2833","authenticated-orcid":false,"given":"ShaoMing","family":"Wang","sequence":"first","affiliation":[{"name":"National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"Metabolic Epidemiology Branch, Division of Cancer Epidemiology &amp; Genetics National Cancer Institute, National Institutes of Health  Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal D.","family":"Freedman","sequence":"additional","affiliation":[{"name":"Metabolic Epidemiology Branch, Division of Cancer Epidemiology &amp; Genetics National Cancer Institute, National Institutes of Health  Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erikka","family":"Loftfield","sequence":"additional","affiliation":[{"name":"Metabolic Epidemiology Branch, Division of Cancer Epidemiology &amp; Genetics National Cancer Institute, National Institutes of Health  Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Hua","sequence":"additional","affiliation":[{"name":"Biostatistics Branch, Division of Cancer Epidemiology &amp; Genetics National Cancer Institute, National Institutes of Health  Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian C.","family":"Abnet","sequence":"additional","affiliation":[{"name":"Metabolic Epidemiology Branch, Division of Cancer Epidemiology &amp; Genetics National Cancer Institute, National Institutes of Health  Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e32833d936d"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60746-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70099-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70326-2"},{"key":"e_1_2_7_6_1","unstructured":"World Cancer Research Fund International\/American Institute for Cancer Research.Continuous update project report: diet nutrition physical activity and stomach cancer 2016. 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