{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:01:14Z","timestamp":1782990074830,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572554"],"award-info":[{"award-number":["81572554"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2014HM070"],"award-info":[{"award-number":["ZR2014HM070"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Activation of the FOXM1 signaling pathway and the PI3K\/AKT\/mTOR signaling pathway is associated with poor prognosis in ovarian cancer. In this study, we demonstrated that P15<jats:sup>PAF<\/jats:sup> (KIAA0101) was significantly upregulated in high\u2010grade serous ovarian cancer (HGSOC) and that high KIAA0101 expression was associated with poor prognosis. FOXM1 transcriptionally activated KIAA0101 to drive proliferation and metastasis of ovarian cancer cells. KIAA0101 activated the PI3K\/AKT\/mTOR signaling pathway to inhibit cisplatin\u2010induced apoptosis and autophagy in ovarian cancer cells resulting in cisplatin resistance. Thus, KIAA0101 was closely related to the FOXM1 and PI3K\/AKT\/mTOR signaling pathways. Collectively, these findings provide insights into the mechanisms of poor prognosis of ovarian cancer and have implications for the development of both predictive and therapeutic biomarkers for the treatment of ovarian cancer.<\/jats:p>","DOI":"10.1002\/ijc.31800","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T15:46:41Z","timestamp":1534952801000},"page":"2973-2984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["PCNA\u2010associated factor P15<sup>PAF<\/sup>, targeted by FOXM1, predicts poor prognosis in high\u2010grade serous ovarian cancer patients"],"prefix":"10.1002","volume":"143","author":[{"given":"Chengjuan","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital, Shandong University  107 Wenhua Xi Road, Jinan China"},{"name":"Department of Obstetrics and Gynecology Shanghai General Hospital, School of 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