{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:16:01Z","timestamp":1793711761857,"version":"4.6.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Antihypertensive (anti\u2010HT) drugs targeting renin\u2010angiotensin\u2010aldosterone (RAA)\u2010 system have been associated with improved prostate cancer (PCa)\u2010specific survival. Challenge is that often multiple drugs are used simultaneously. We evaluated the association between use of anti\u2010HT drugs and PCa survival among 14,422 surgically treated Finnish PCa patients. Information on drug purchases was obtained from a national prescription database. We used Cox regression to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for risk of PCa death and initiation of androgen deprivation therapy (ADT) with adjustment for age, tumor extent, use of statins and for Charlson Comorbidity Index. Angiotensin\u2010converting enzyme (ACE)\u2010 inhibitors, angiotensin\u2010 receptor (ATR)\u2010blockers, diuretics, calcium\u2010channel blockers, beta\u2010blockers and other anti\u2010HT drugs were analyzed as separate time\u2010dependent variables to model simultaneous use. Overall anti\u2010HT drugs were associated with an increased risk of PCa death. Conversely use of ATR\u2010blockers was associated with decreased risk of PCa death (HR: 0.43, 95% CI: 0.26\u20130.72 and HR: 0.60, 95% CI 0.37\u20130.97 for pre\u2010 and post\u2010diagnostic use). Similar risk decrease was not observed in other drug groups. Anti\u2010HT drugs were also associated with an increased risk of starting ADT, with the exception of ATR\u2010blockers (HR: 0.81 CI:0.71\u20130.92). ATR\u2010 blockers differ from other anti\u2010HT drugs as the survival is better in users of this drug group. The result partly supports the role of RAA system in PCa progression. Nevertheless, the risk decrease was not observed in ACE\u2010inhibitor users. Further research is needed to elucidate the molecular mechanism for the potential anticancer effect of ATR\u2010 blockers.<\/jats:p>","DOI":"10.1002\/ijc.31802","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T12:58:52Z","timestamp":1534337932000},"page":"440-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Antihypertensive drugs and prostate cancer survival after radical prostatectomy in Finland\u2014A nationwide cohort study"],"prefix":"10.1002","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-0046","authenticated-orcid":false,"given":"Eerik EE","family":"Santala","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Life Sciences University of Tampere  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Rannikko","sequence":"additional","affiliation":[{"name":"Department of Urology Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teemu J","family":"Murtola","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences University of Tampere  Tampere Finland"},{"name":"Department of Urology Tampere University Hospital  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31358"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medici.2016.03.002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9477-x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.11.013"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.01.003"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(01)00246-0"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-011-9819-3"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000269"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-005-0520-y"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e2697"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70106-6"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000036152.58271.5e"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.10294"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/028418602760169442"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq433"},{"key":"e_1_2_5_17_1","unstructured":"WHOATC\/DDD index database. 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