{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T15:19:27Z","timestamp":1769095167739,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"UICC Cervical Cancer Initiative Seed Grant, Maharashtra Foundation, USA, Emcure, Ranbaxy, Sun Pharma, Serum Institute of India and Cipla Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>We report the incidence of cervical intraepithelial neoplasia (CIN) among HIV\u2010infected women who did not have any colposcopic or histopathological evidence of CIN at baseline. Of the 1,023 women without any CIN at baseline, 855 (83.6%) have been followed up to a maximum of 6.4 years contributing 2,875 person years of observation (PYO). Among these 855 women, 54 cases of any CIN were observed resulting in incidence rate of any CIN of 1.9 per 100 PYO. The median time for follow\u2010up for women with any CIN was 3.0 (IQR 1.6\u20133.7) years. The cumulative incidence rate per 100 PYO of CIN 2 or worse lesion in women with HPV\u201018 infection at baseline was 13.3% (95% CI 5.1\u201326.8); in women with HPV\u201016 infection was 10.8% (95% CI 4.4\u201320.9); in women with HPV\u201031 infection was 4.2% (95% CI 0.9\u201311.7); and in women with other high\u2010risk HPV infections was 5.4% (95% CI 2.6\u20139.7). HPV\u201018 infection at baseline contributed highest frequency of incident CIN 2 or worse lesions followed by HPV\u201016 infection; however, other high\u2010risk HPV types were also responsible for substantial number of incident CIN. The elevated risk of CIN2+ disease in the study cohort was non\u2010significant in women with CD4 count &lt;200, possibly because of the small number of cases. Our results emphasize the need for regular cervical cancer screening of HIV\u2010infected women and urgent implementation of cervical cancer screening services in HIV programs in India and other low and middle\u2010income countries.<\/jats:p>","DOI":"10.1002\/ijc.31826","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T17:01:51Z","timestamp":1534957311000},"page":"1082-1091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Incidence of cervical intraepithelial neoplasia in women infected with human immunodeficiency virus (HIV) with no evidence of disease at baseline: Results of a prospective cohort study with up to 6.4 years of follow\u2010up from India"],"prefix":"10.1002","volume":"144","author":[{"given":"Smita","family":"Joshi","sequence":"first","affiliation":[{"name":"Department of Preventive Oncology Prayas and HCJMRI  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Muwonge","sequence":"additional","affiliation":[{"name":"Screening Group International Agency for Research on Cancer  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Prayas  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kedar","family":"Deodhar","sequence":"additional","affiliation":[{"name":"Department of Pathology Tata Memorial Centre  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh","family":"Mandolkar","sequence":"additional","affiliation":[{"name":"Prayas  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Lucas","sequence":"additional","affiliation":[{"name":"Screening Group International Agency for Research on Cancer  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2595-6642","authenticated-orcid":false,"given":"Rengaswamy","family":"Sankaranarayanan","sequence":"additional","affiliation":[{"name":"Screening Group International Agency for Research on Cancer  Lyon France"},{"name":"Research Triangle Institute International\u2010India Commercial Tower  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27711"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113512531"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit181"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462413491735"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23487"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832b4449"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2011-050346"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji073"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.045"},{"key":"e_1_2_8_13_1","first-page":"1","article-title":"1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults","volume":"41","year":"1992","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000253361.63578.14"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e3282f75ea1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122169"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835b1041"},{"key":"e_1_2_8_18_1","volume-title":"Comprehensive cervical cancer control \u2010 a guide to essential practice","author":"WHO","year":"2014"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144905"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.12.060"},{"key":"e_1_2_8_21_1","volume-title":"A practical manual on visual screening for cervical neoplasia. 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