{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:59:59Z","timestamp":1760122799954,"version":"3.40.5"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Institute of Health Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Our study aimed to evaluate the relevance of genetic susceptibility in the development of colorectal adenomas (CRA) and its relationship with the presence of family history of colorectal cancer (CRC). Genomic DNA from 750 cases (first degree relatives of patients with CRC) and 750 controls (subjects with no family history of CRC) was genotyped for 99 single nucleotide polymorphisms (SNPs) previously associated with CRC\/CRA risk by GWAS and candidate gene studies by using the MassArray\u2122 (Sequenom) platform. Cases and controls were matched by gender, age and histological lesion. Eight hundred and fifty\u2010eight patients showed no neoplastic lesions, whereas 288 patients showed low\u2010risk adenomas, and 354 patients presented high\u2010risk adenomas. Two SNPs (rs10505477, rs6983267) in the CASC8 gene were associated with a reduced risk of CRA in controls (log\u2010additive models, OR: 0.67, 95%CI:0.54\u20130.83, and OR:0.66, 95%CI:0.54\u20130.84, respectively). Stratified analysis by histological lesion revealed the association of rs10505477 and rs6983267 variants with reduced risk of low\u2010 and high\u2010risk adenomas in controls, being this effect stronger in low\u2010risk adenomas (log\u2010additive models, OR:0.63, 95%CI:0.47\u20130.84 and OR:0.64, 95%CI:0.47\u20130.86, respectively). Moreover, 2 SNPs (rs10795668, rs11255841) in the noncoding LINC00709 gene were significantly associated with a reduced risk of low\u2010risk adenomas in cases (recessive models, OR:0.22, 95%CI:0.06\u20130.72, and OR:0.08, 95%CI:0.03\u20130.61) and controls (dominant models, OR:0.50, 95%CI:0.34\u20130.75, and OR:0.52, 95%CI:0.35\u20130.78, respectively). In conclusion, some variants associated with CRC risk (rs10505477, rs6983267, rs10795668 and rs11255841) are also involved in the susceptibility to CRA and specific subtypes. These associations are influenced by the presence of family history of CRC.<\/jats:p>","DOI":"10.1002\/ijc.31858","type":"journal-article","created":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T13:02:50Z","timestamp":1536411770000},"page":"489-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Genetic susceptibility in the development of colorectal adenomas according to family history of colorectal cancer"],"prefix":"10.1002","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3545-2707","authenticated-orcid":false,"given":"Carla J.","family":"Gargallo","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednico Universitario Lozano Blesa  Zaragoza Spain"},{"name":"Aragon Health Research Institute (IIS Aragon)  Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel","family":"Lanas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednico Universitario Lozano Blesa  Zaragoza Spain"},{"name":"Aragon Health Research Institute (IIS Aragon)  Zaragoza Spain"},{"name":"University of Zaragoza School of Medicine  Zaragoza Spain"},{"name":"CIBERehd  Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Carrera\u2010Lasfuentes","sequence":"additional","affiliation":[{"name":"CIBERehd  Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel","family":"Ferrandez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednico Universitario Lozano Blesa  Zaragoza Spain"},{"name":"Aragon Health Research Institute (IIS Aragon)  Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Quintero","sequence":"additional","affiliation":[{"name":"University of La Laguna, School of Medicine  Canary Islands Spain"},{"name":"Hospital Universitario de Canarias  Canary Islands Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Canarias  Canary Islands Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Alonso\u2010Abreu","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Canarias  Canary Islands Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Asunci\u00f3n","family":"Garc\u00eda\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Aragon Health Research Institute (IIS Aragon)  Zaragoza Spain"},{"name":"CIBERehd  Zaragoza Spain"},{"name":"Aragon Institute of Health Sciences (IACS)  Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"FerlayJ SoerjomataramI ErvikM et al. 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