{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:14:03Z","timestamp":1788383643759,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T00:00:00Z","timestamp":1544227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["No. 2017\u2010374"],"award-info":[{"award-number":["No. 2017\u2010374"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2019,3,15]]},"abstract":"<jats:p>The link between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is widely recognized. Considering the strong association between raised antithyroidperoxidase antibody (TPOAb) and CLT, we postulated that the preoperative TPOAb can predict the prognosis of PTC, particularly for recurrence. A total of 2,070 patients who underwent total thyroidectomy for classical type PTC with tumor size \u22651 cm and with available data on preoperative TPOAb and TgAb were enrolled to compare disease\u2010free survival (DFS) according to the presence of preoperative TPOAb, TgAb, and coexistent CLT. Patients with positive preoperative TPOAb had a significantly better DFS compared to patients without positive preoperative TPOAb (hazard ratio (HR) 0.53; 95% confidence interval (CI) 0.30\u20130.94, <jats:italic>p<\/jats:italic> = 0.028) while no difference in DFS was found according to preoperative TgAb status. Positive preoperative TPOAb was an independent prognostic factor for structural persistent\/recurrent disease after adjustment for major preoperative risk factors such as age, sex, and tumor size (HR 0.52, 95% CI 0.28\u20130.99, <jats:italic>p<\/jats:italic> = 0.048). Although the coexistence of CLT lowered the risk for structural persistence\/recurrence in univariate analysis (HR 0.52, 95% CI 0.31\u20130.86, <jats:italic>p<\/jats:italic> = 0.012), it was not an independent favorable prognostic factor by multivariate analysis (HR 0.65, 95% CI 0.38\u20131.10, <jats:italic>p<\/jats:italic> = 0.106). However, when coexistent CLT was combined with positive preoperative TPOAb, it indicated an independent protective role in structural persistent\/recurrent disease (HR 0.39, 95% CI 0.16\u20130.98, <jats:italic>p<\/jats:italic> = 0.045). Our study clearly showed that presence of preoperative TPOAb can be a novel prognostic factor in predicting structural persistence\/recurrence of PTC.<\/jats:p>","DOI":"10.1002\/ijc.31944","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T08:49:30Z","timestamp":1540457370000},"page":"1414-1420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The value of preoperative antithyroidperoxidase antibody as a novel predictor of recurrence in papillary thyroid carcinoma"],"prefix":"10.1002","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6034-0758","authenticated-orcid":false,"given":"Eyun","family":"Song","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Seon","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1297-107X","authenticated-orcid":false,"given":"Min Ji","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Wook","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Surgery Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suck Joon","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Surgery Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Sook","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Nuclear medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hwan","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Radiology Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0021-4477","authenticated-orcid":false,"given":"Jeong Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Gu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Kee","family":"Shong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Yong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,8]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"537","article-title":"Standpoints in scientific medicine, 1877","volume":"30","author":"Virchow R","year":"1956","journal-title":"Bull Hist Med"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04046-0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.01.013"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2007.09.020"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812472426"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1309"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.197"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-011-9164-9"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13475"},{"key":"e_1_2_5_12_1","first-page":"1","article-title":"The association between papillary carcinoma and chronic lymphocytic thyroiditis: does it modify the prognosis of cancer?","volume":"33","author":"Del Rio P","year":"2008","journal-title":"Minerva Endocrinol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2099.101431"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2016.31.4.493"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302013000300005"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0962"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01592.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1740"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13367"},{"key":"e_1_2_5_20_1","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1001\/archinte.1993.00410070050007","article-title":"The superiority of antimicrosomal over antithyroglobulin antibodies for detecting Hashimoto's thyroiditis","volume":"153","author":"Nordyke RA","year":"1993","journal-title":"Arch Intern Med"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/1050725041517057"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9695-y"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03537.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp127"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.09.001"},{"key":"e_1_2_5_27_1","first-page":"286","article-title":"Inflammation in thyroid oncogenesis","volume":"2","author":"Liotti F","year":"2012","journal-title":"Am J Cancer Res"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2016.31.3.379"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.2.596"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04482.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90346-9"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5302.960"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680020165"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.31944","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.31944","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.31944","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.31944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T23:47:55Z","timestamp":1694735275000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.31944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,8]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,3,15]]}},"alternative-id":["10.1002\/ijc.31944"],"URL":"https:\/\/doi.org\/10.1002\/ijc.31944","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,8]]},"assertion":[{"value":"2018-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}