{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:11:07Z","timestamp":1787062267240,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chinese Academy of Medical Sciences (CAMS) Initiative Medicine (CAMS-I2M)","award":["2017-I2M-1-001"],"award-info":[{"award-number":["2017-I2M-1-001"]}]},{"name":"Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences","award":["2018PT32014"],"award-info":[{"award-number":["2018PT32014"]}]},{"name":"Peking Union Medical College Innovative Team Development Program (2016)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>\n                    Parathyroid carcinoma (PC) is a rare endocrine malignancy. Surgical resection is curative for local lesions, while effective therapies are lacking for recurrent or metastatic PCs. To study whether targeted therapies could be applied in recurrent or metastatic PCs, potential therapeutic targets were identified with next\u2010generation sequencing (NGS). DNA was extracted from formalin\u2010fixed, paraffin\u2010embedded (FFPE) sections from 19 recurrent or metastatic PC samples. A panel of 560 genes was sequenced with NGS to identify genomic alterations at an average sequencing depth of 581\u00d7. In total, 190 genomic alterations were identified. Nine PC samples (47%) harbored at least one potentially actionable genomic alteration including in the after genes:\n                    <jats:italic>ROS1<\/jats:italic>\n                    (5\/19; 26%),\n                    <jats:italic>PTEN<\/jats:italic>\n                    (3\/19; 16%),\n                    <jats:italic>TSC1<\/jats:italic>\n                    (2\/19; 11%),\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    (1\/19; 5%),\n                    <jats:italic>AKT1<\/jats:italic>\n                    (1\/19; 5%),\n                    <jats:italic>MTOR<\/jats:italic>\n                    (1\/19; 5%),\n                    <jats:italic>ERBB2<\/jats:italic>\n                    (1\/19; 5%),\n                    <jats:italic>NTRK1<\/jats:italic>\n                    (1\/19; 5%),\n                    <jats:italic>IDH1<\/jats:italic>\n                    (1\/19; 5%) and\n                    <jats:italic>FGFR3<\/jats:italic>\n                    (1\/19; 5%).\n                    <jats:italic>CDC73<\/jats:italic>\n                    mutations were detected in 9\/19 (47%) PC samples. Additional recurrent genomic alterations were identified in\n                    <jats:italic>MSH2<\/jats:italic>\n                    (15\/19; 79%),\n                    <jats:italic>AR<\/jats:italic>\n                    (9\/19; 47%),\n                    <jats:italic>BCR<\/jats:italic>\n                    (8\/19; 42%),\n                    <jats:italic>SLC45A3<\/jats:italic>\n                    (6\/19; 32%),\n                    <jats:italic>MAGI1<\/jats:italic>\n                    (5\/19; 26%),\n                    <jats:italic>ZNF521<\/jats:italic>\n                    (4\/19; 21%),\n                    <jats:italic>KMT2C<\/jats:italic>\n                    (4\/19; 21%) and\n                    <jats:italic>NOTCH4<\/jats:italic>\n                    (4\/19; 21%). Our study identified a relatively high frequency of potentially actionable genomic alterations in PC patients in a Chinese population for the first time. A series of recurrent mutant genes was detected as well. Our study contributes to both the selection of novel targeted therapies for PC and further molecular understanding of this refractory malignancy.\n                  <\/jats:p>","DOI":"10.1002\/ijc.31948","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T08:06:22Z","timestamp":1540541182000},"page":"525-532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Preliminary exploration of potential molecular therapeutic targets in recurrent and metastatic parathyroid carcinomas"],"prefix":"10.1002","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-4585","authenticated-orcid":false,"given":"Ming","family":"Cui","sequence":"first","affiliation":[{"name":"Department of General Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing 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