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The treatment options for cancer cachexia are limited, and the molecular mechanism remains poorly understood. Circular RNAs (circRNAs) are a novel family of endogenous noncoding RNAs that have been proposed to regulate gene expression in mammals. Exosomes are small vesicles derived from cells, and recent studies have shown that circRNAs are stable in exosomes. However, little is known about the biological role of circRNAs in exosomes. In our study, we showed that circRNAs in plasma exosomes have specific expression features in gastric cancer (GC), and ciRS\u2010133 is linked with the browning of white adipose tissue (WAT) in GC patients. Exosomes derived from GC cells deliver ciRS\u2010133 into preadipocytes, promoting the differentiation of preadipocytes into brown\u2010like cells by activating PRDM16 and suppressing miR\u2010133. Moreover, knockdown of ciRS\u2010133 reduced cancer cachexia in tumor\u2010implanted mice, decreasing oxygen consumption and heat production. 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