{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:54:24Z","timestamp":1790290464326,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T00:00:00Z","timestamp":1547942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP\u201086727"],"award-info":[{"award-number":["MOP\u201086727"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007558","name":"Rutgers Cancer Institute of New Jersey","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001282","name":"Ovarian Cancer Research Fund","doi-asserted-by":"publisher","award":["PPD\/RPCI.074"],"award-info":[{"award-number":["PPD\/RPCI.074"]}],"id":[{"id":"10.13039\/100001282","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008658","name":"Deutsches Krebsforschungszentrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["94 222 52"],"award-info":[{"award-number":["94 222 52"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation for Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000182","name":"Medical Research and Materiel Command","doi-asserted-by":"publisher","award":["DAMD17\u201001\u20101\u20100729"],"award-info":[{"award-number":["DAMD17\u201001\u20101\u20100729"]}],"id":[{"id":"10.13039\/100000182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003135","name":"Minnesota Ovarian Cancer Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1 R01CA160669\u201001A1, K07\u2010CA080668, NIH\u2010K07 CA095666, NIH\u2010K22\u2010CA138563, P30 CA04, P30 CA046592, P30\u2010CA008748, P30\u2010CA072720, P50\u2010CA159981, R01 CA076016, R01\u2010CA61107, R01\u2010CA83918, R01\u2010CA95023, R21\u2010CA222867"],"award-info":[{"award-number":["1 R01CA160669\u201001A1, K07\u2010CA080668, NIH\u2010K07 CA095666, NIH\u2010K22\u2010CA138563, P30 CA04, P30 CA046592, P30\u2010CA008748, P30\u2010CA072720, P50\u2010CA159981, R01 CA076016, R01\u2010CA61107, R01\u2010CA83918, R01\u2010CA95023, R21\u2010CA222867"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["M01\u2010RR000056"],"award-info":[{"award-number":["M01\u2010RR000056"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1043134, 199600, ID400281, ID400413, 209057, 396414, 1074383"],"award-info":[{"award-number":["1043134, 199600, ID400281, ID400413, 209057, 396414, 1074383"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["NIH ES 20811 BM"],"award-info":[{"award-number":["NIH ES 20811 BM"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K22 CA193860, N01\u2010CN\u201055424, N01\u2010PC\u201067001, N01CN025403, N01PC67010, P01 CA87969, P01CA17054, P30\u2010CA15083, P30CA14089, P50\u2010CA105009, P50\u2010CA136393, R01 CA49449, R01\u2010CA0568860, R01\u2010CA063678, R01\u2010CA074850, R01\u2010CA080742, R01\u2010CA112523, R01\u2010CA122443, R01\u2010CA54419, R01\u2010CA58598, R01\u2010CA67262, R01\u2010CA76016, R01\u2010CA87538, R01CA61132, R03CA113148, R03CA115195, T32 ES013678, U01 CA69417, U01 CA71966, UM1 CA176726, UM1 CA186107"],"award-info":[{"award-number":["K22 CA193860, N01\u2010CN\u201055424, N01\u2010PC\u201067001, N01CN025403, N01PC67010, P01 CA87969, P01CA17054, P30\u2010CA15083, P30CA14089, P50\u2010CA105009, P50\u2010CA136393, R01 CA49449, R01\u2010CA0568860, R01\u2010CA063678, R01\u2010CA074850, R01\u2010CA080742, R01\u2010CA112523, R01\u2010CA122443, R01\u2010CA54419, R01\u2010CA58598, R01\u2010CA67262, R01\u2010CA76016, R01\u2010CA87538, R01CA61132, R03CA113148, R03CA115195, T32 ES013678, U01 CA69417, U01 CA71966, UM1 CA176726, UM1 CA186107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["NSF DMS 1406712 BM"],"award-info":[{"award-number":["NSF DMS 1406712 BM"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011928","name":"Ovarian Cancer Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["223175 HEALTH F2 2009\u2010223175"],"award-info":[{"award-number":["223175 HEALTH F2 2009\u2010223175"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["DAMD17\u201002\u20101\u20100666DAMD17\u201002\u20101\u20100669W81XWH\u201010\u20101\u201002802"],"award-info":[{"award-number":["DAMD17\u201002\u20101\u20100666DAMD17\u201002\u20101\u20100669W81XWH\u201010\u20101\u201002802"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004824","name":"State of Connecticut Department of Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004824","name":"State of Connecticut Department of Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>As a follow\u2010up to genome\u2010wide association analysis of common variants associated with ovarian carcinoma (cancer), our study considers seven well\u2010known ovarian cancer risk factors and their interactions with 28 genome\u2010wide significant common genetic variants. The interaction analyses were based on data from 9971 ovarian cancer cases and 15,566 controls from 17 case\u2013control studies. Likelihood ratio and Wald tests for multiplicative interaction and for relative excess risk due to additive interaction were used. The top multiplicative interaction was noted between oral contraceptive pill (OCP) use (ever <jats:italic>vs<\/jats:italic>. never) and rs13255292 (<jats:italic>p<\/jats:italic> value = 3.48 \u00d7 10<jats:sup>\u22124<\/jats:sup>). Among women with the TT genotype for this variant, the odds ratio for OCP use was 0.53 (95% CI = 0.46\u20130.60) compared to 0.71 (95%CI = 0.66\u20130.77) for women with the CC genotype. When stratified by duration of OCP use, women with 1\u20135 years of OCP use exhibited differential protective benefit across genotypes. However, no interaction on either the multiplicative or additive scale was found to be statistically significant after multiple testing correction. The results suggest that OCP use may offer increased benefit for women who are carriers of the T allele in rs13255292. On the other hand, for women carrying the C allele in this variant, longer (5+ years) use of OCP may reduce the impact of carrying the risk allele of this SNP. Replication of this finding is needed. The study presents a comprehensive analytic framework for conducting gene\u2013environment analysis in ovarian cancer.<\/jats:p>","DOI":"10.1002\/ijc.32029","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T07:34:03Z","timestamp":1543563243000},"page":"2192-2205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A comprehensive gene\u2013environment interaction analysis in Ovarian Cancer using genome\u2010wide significant common variants"],"prefix":"10.1002","volume":"144","author":[{"given":"Sehee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Tyrer","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Virus, Lifestyle and Genes Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Wiensch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Michigan School of Public Health  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Harvard T.H. Chan School of Public Health  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Public Health California State University, Fullerton  Fullerton CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta B.","family":"Ness","sequence":"additional","affiliation":[{"name":"University of Texas School of Public Health  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-1514","authenticated-orcid":false,"given":"Maxwell","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health  Ann Arbor MI USA"},{"name":"Department of Epidemiology University of Michigan School of Public Health  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley S.","family":"Tworoger","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology Moffitt Cancer Center  Tampa FL USA"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice S.","family":"Whittemore","sequence":"additional","affiliation":[{"name":"Department of Health Research and Policy \u2010 Epidemiology Stanford University School of Medicine  Stanford CA USA"},{"name":"Department of Biomedical Data Science Stanford University School of Medicine  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9603-0110","authenticated-orcid":false,"given":"Hoda","family":"Anton\u2010Culver","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Genetic Epidemiology Research Institute, University of California Irvine  Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiva","family":"Sieh","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Department of Population Health Science and Policy Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara H.","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan\u2010Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Berchuck","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Duke University Medical Center  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9094-8326","authenticated-orcid":false,"given":"Ellen L.","family":"Goode","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc T.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Cancer Prevention and Control Samuel Oschin Comprehensive Cancer Institute, Cedars\u2010Sinai Medical Center  Los Angeles CA USA"},{"name":"Department of Biomedical Sciences, Cedars\u2010Sinai Medical Center Community and Population Health Research Institute  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Anne","family":"Doherty","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Huntsman Cancer Institute, University of Utah  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Chenevix\u2010Trench","sequence":"additional","affiliation":[{"name":"Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Anne","family":"Rossing","sequence":"additional","affiliation":[{"name":"Program in Epidemiology, Division of Public Health Sciences Fred Hutchinson Cancer Research Center  Seattle WA USA"},{"name":"Department of Epidemiology University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope M.","family":"Webb","sequence":"additional","affiliation":[{"name":"Population Health Department QIMR Berghofer Medical Research Institute  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham G.","family":"Giles","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology &amp; Intelligence Division Cancer Council Victoria  Melbourne VIC Australia"},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L.","family":"Terry","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health  Boston MA USA"},{"name":"Obstetrics and Gynecology Epidemiology Center Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argyrios","family":"Ziogas","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Genetic Epidemiology Research Institute, University of California Irvine  Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1426-8505","authenticated-orcid":false,"given":"Ren\u00e9e T.","family":"Fortner","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Menon","sequence":"additional","affiliation":[{"name":"Gynaecological Cancer Research Centre, Women's Cancer Institute for Women's Health, University College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Gayther","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine University of Southern California  Los Angeles CA USA"},{"name":"Center for Cancer Prevention and Translational Genomics Samuel Oschin Comprehensive Cancer Institute, Cedars\u2010Sinai Medical Center  Los Angeles CA USA"},{"name":"Department of Biomedical Sciences Cedars\u2010Sinai Medical Center  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0546-902X","authenticated-orcid":false,"given":"Anna H.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine University of Southern California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Song","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Brooks\u2010Wilson","sequence":"additional","affiliation":[{"name":"Genome Sciences Centre BC Cancer Agency  Vancouver BC Canada"},{"name":"Department of Biomedical Physiology and Kinesiology Simon Fraser University  Burnaby BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa V.","family":"Bandera","sequence":"additional","affiliation":[{"name":"Cancer Prevention and Control Program Rutgers Cancer Institute of New Jersey  New Brunswick NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S.","family":"Cook","sequence":"additional","affiliation":[{"name":"University of New Mexico Health Sciences Center University of New Mexico  Albuquerque NM USA"},{"name":"Division of Cancer Care, Department of Population Health Research Alberta Health Services  Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8024-3066","authenticated-orcid":false,"given":"Daniel W.","family":"Cramer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health  Boston MA USA"},{"name":"Obstetrics and Gynecology Epidemiology Center Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Milne","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology &amp; Intelligence Division Cancer Council Victoria  Melbourne VIC Australia"},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"Precision Medicine, School of Clinical Sciences at Monash Health Monash University  Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey J.","family":"Winham","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne K.","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Department of Virus, Lifestyle and Genes Danish Cancer Society Research Center  Copenhagen Denmark"},{"name":"Department of Gynaecology, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0637-1534","authenticated-orcid":false,"given":"Francesmary","family":"Modugno","sequence":"additional","affiliation":[{"name":"Ovarian Cancer Center of Excellence, Womens Cancer Research Program Magee\u2010Womens Research Institute and Hillman Cancer Center  Pittsburgh PA USA"},{"name":"Department of Epidemiology University of Pittsburgh Graduate School of Public Health  Pittsburgh PA USA"},{"name":"Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences University of Pittsburgh School of Medicine  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Cancer Prevention and Control Samuel Oschin Comprehensive Cancer Institute, Cedars\u2010Sinai Medical Center  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Chang\u2010Claude","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Cancer Epidemiology Group University Cancer Center Hamburg (UCCH), University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly R.","family":"Harris","sequence":"additional","affiliation":[{"name":"Program in Epidemiology, Division of Public Health Sciences Fred Hutchinson Cancer Research Center  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joellen M.","family":"Schildkraut","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Virginia  Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhu D.","family":"Le","sequence":"additional","affiliation":[{"name":"Cancer Control Research BC Cancer Agency  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Wentzensen","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1539-6090","authenticated-orcid":false,"given":"Britton","family":"Trabert","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estrid","family":"H\u00f8gdall","sequence":"additional","affiliation":[{"name":"Department of Virus, Lifestyle and Genes Danish Cancer Society Research Center  Copenhagen Denmark"},{"name":"Molecular Unit, Department of Pathology Herlev Hospital, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Huntsman","sequence":"additional","affiliation":[{"name":"British Columbia's Ovarian Cancer Research (OVCARE) program Vancouver General Hospital, BC Cancer and University of British Columbia"},{"name":"Department of Pathology and Laboratory Medicine, and Obstetrics and Gynecology University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4891-1199","authenticated-orcid":false,"given":"Malcolm C.","family":"Pike","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan\u2010Kettering Cancer Center  New York NY USA"},{"name":"Department of Preventive Medicine, Keck School of Medicine University of Southern California Norris Comprehensive Cancer Center  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.P.","family":"Pharoah","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge  Cambridge United Kingdom"},{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-7846","authenticated-orcid":false,"given":"Celeste Leigh","family":"Pearce","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Michigan School of Public Health  Ann Arbor MI USA"},{"name":"Center for Cancer Prevention and Translational Genomics Samuel Oschin Comprehensive Cancer Institute, Cedars\u2010Sinai Medical Center  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhramar","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,20]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Society AC. Cancer Facts & Figures 2017. American Cancer Society2017."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01224-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-1030-T"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt431"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt042"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju410"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.10.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12516"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.12.003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2566"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.666"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.668"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-1227"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3336"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3185"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2613"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2564"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3826"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2629"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.424"},{"key":"e_1_2_7_22_1","first-page":"46","article-title":"Cancer incidence in the first\u2010degree relatives of ovarian cancer patients","volume":"113","author":"Auranen A","year":"1997","journal-title":"Duodecim; laaketieteellinen aikakauskirja"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10148.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001387"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23956"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61687-1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-12-0395"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70404-1"},{"key":"e_1_2_7_29_1","unstructured":"SEER Cancer Statistics Review1975\u20102014 Based on November 2016 SEER data submission posted to the SEER web site April 2017."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-1128"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx243"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2388"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-011-9554-9"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx243"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr334"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1515\/2161-962X.1010"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2011.02509.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119013563"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003284"},{"key":"e_1_2_7_40_1","unstructured":"BhattacharjeeSCn Han SandWheelerW. CGEN: An R package for analysis of case\u2010control studies in genetic epidemiology 2012."},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws166"},{"key":"e_1_2_7_42_1","volume-title":"Cancer stat facts: Ovarian Cancer","author":"SEER"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2015"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30150"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.4161\/23723556.2014.974467"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068537"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2011-1037"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30274"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-1039"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kww143"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx227"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.32029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.32029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.32029","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/ijc.32029","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.32029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T06:58:05Z","timestamp":1751007485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.32029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,20]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/ijc.32029"],"URL":"https:\/\/doi.org\/10.1002\/ijc.32029","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,20]]},"assertion":[{"value":"2018-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}