{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:10:27Z","timestamp":1787238627433,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:00:00Z","timestamp":1546819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Danish Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n                    Up to 60% of patients treated with cancer immunotherapy develop severe or life threatening immune\u2010related adverse events (irAEs). Immunosuppression with high dose corticosteroids, or tumor necrosis factor (TNF) antagonists in refractory cases, is the mainstay of treatment for irAEs. It is currently unknown what impact corticosteroids and anti\u2010TNF have on the activity of antitumor T cells. In our study, the influence of clinically relevant doses of dexamethasone (corresponding to an oral dose of 10\u2013125 mg prednisolone) and infliximab (anti\u2010TNF) on the activation and killing ability of tumor\u2010infiltrating lymphocytes (TILs) was tested\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Overall, dexamethasone at low or intermediate\/high doses impaired the activation (\u221246 and \u221262%, respectively) and tumor\u2010killing ability (\u221248 and \u221253%, respectively) of tumor\u2010specific TILs. In contrast, a standard clinical dose of infliximab only had a minor effect on T cell activation (\u221220%) and tumor killing (\u221210%). A 72\u2010hr resting period after withdrawal of dexamethasone was sufficient to rescue the\n                    <jats:italic>in vitro<\/jats:italic>\n                    activity of TILs, while a short withdrawal did not result in a full rescue. In conclusion, clinically relevant doses of infliximab only had a minor influence on the activity of tumor\u2010specific TILs\n                    <jats:italic>in vitro<\/jats:italic>\n                    , whereas even low doses of corticosteroids markedly impaired the antitumor activity of TILs. However, the activity of TILs could be restored after withdrawal of steroids. These data indirectly support steroid\u2010sparing strategies and early initiation of anti\u2010TNF therapy for the treatment of irAEs in immuno\u2010oncology.\n                  <\/jats:p>","DOI":"10.1002\/ijc.32080","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T16:48:06Z","timestamp":1545410886000},"page":"1408-1413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Differential effects of corticosteroids and anti\u2010TNF on tumor\u2010specific immune responses: implications for the management of irAEs"],"prefix":"10.1002","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5894-6750","authenticated-orcid":false,"given":"Arianna","family":"Draghi","sequence":"first","affiliation":[{"name":"Department of Hematology Center for Cancer Immune Therapy, Herlev and Gentofte Hospital, University of Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4402-9281","authenticated-orcid":false,"given":"Troels Holz","family":"Borch","sequence":"additional","affiliation":[{"name":"Department of Hematology Center for Cancer Immune Therapy, Herlev and Gentofte Hospital, University of Copenhagen  Herlev Denmark"},{"name":"Department of Oncology Herlev and Gentofte Hospital, University of Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haja Dominike","family":"Radic","sequence":"additional","affiliation":[{"name":"Department of Hematology Center for Cancer Immune Therapy, Herlev and Gentofte Hospital, University of Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Aled","family":"Chamberlain","sequence":"additional","affiliation":[{"name":"Department of Hematology Center for Cancer Immune Therapy, Herlev and Gentofte Hospital, University of Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya","family":"Gokuldass","sequence":"additional","affiliation":[{"name":"Department of Hematology Center for Cancer Immune Therapy, Herlev and Gentofte Hospital, University of Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge Marie","family":"Svane","sequence":"additional","affiliation":[{"name":"Department of Hematology Center for Cancer Immune Therapy, Herlev and Gentofte Hospital, University of Copenhagen  Herlev Denmark"},{"name":"Department of Oncology Herlev and Gentofte Hospital, University of Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-9752","authenticated-orcid":false,"given":"Marco","family":"Donia","sequence":"additional","affiliation":[{"name":"Department of Hematology Center for Cancer Immune Therapy, Herlev and Gentofte Hospital, University of Copenhagen  Herlev Denmark"},{"name":"Department of Oncology Herlev and Gentofte Hospital, University of Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx225"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.11.016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3239"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv623"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.6385"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0047"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-017-1962-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.2018.17"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.60.8448"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.9003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0371-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy139"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2011.02640.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-2956"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-008-9038-3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130301"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284818759930"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3922"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.60.5.563"},{"key":"e_1_2_7_23_1","unstructured":"Europen 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